Li H S, Borg E
Department of Physiology II, Karolinska Institute, Stockholm, Sweden.
Acta Otolaryngol. 1991;111(5):827-34. doi: 10.3109/00016489109138418.
Frequency-specific auditory brainstem responses (ABR) (frequency range 2-31.5 kHz) were used to describe age-dependent alterations in frequency sensitivity in CBA/ca (to 30 months) and C57BL/6J (to 16 months) mouse genotypes. The two strains displayed an age-related loss similar to that of humans, with a primary decline in high-frequency sensitivity. CBA mice showed a slow, yet gradual decrease in sensitivity to high- followed by low-frequency until 18 months of age and a rapid deterioration at all frequencies thereafter. C57 mice demonstrated precocious aging in auditory sensitivity in an unsteady rather than gradual manner. By testing the same individuals on repeated occasions it was shown that, for C57 mice, the degenerative process was more precipitous with three phases, and that the individual variability was larger than that of CBA mice. It is suggested that the two mouse genotypes can be used to express the different aspects of human presbycusis in individual variability and modes of gradual or staggered progression.
使用频率特异性听觉脑干反应（ABR）（频率范围2-31.5kHz）来描述CBA/ca（至30个月）和C57BL/6J（至16个月）小鼠基因型中频率敏感性的年龄依赖性变化。这两个品系表现出与人类相似的年龄相关性听力损失，高频敏感性出现原发性下降。CBA小鼠在18个月龄之前对高频继而低频的敏感性呈现缓慢但逐渐下降的趋势，此后所有频率均迅速恶化。C57小鼠在听觉敏感性方面表现出早熟衰老，且不稳定而非逐渐衰老。通过对相同个体进行重复测试表明，对于C57小鼠，退化过程更为急剧，分为三个阶段，且个体变异性大于CBA小鼠。建议这两种小鼠基因型可用于在个体变异性以及渐进或交错进展模式方面表达人类老年性聋的不同方面。
