Li H S, Johnson A C, Borg E, Höglund G
Department of Physiology II, Karolinska Institute, Stockholm, Sweden.
Arch Toxicol. 1992;66(6):382-6. doi: 10.1007/BF02035126.
Two inbred strains of mice, CBA/Ca (with a moderate hearing loss starting late in life) and C57BL/6J (with an early onset of spontaneous auditory degeneration), were exposed to toluene by inhalation (1000 ppm, 12 h/day, 7 days) at either 1 or 6 months of age. Thresholds of auditory brainstem response (ABR) were measured 3-5 days after exposure and assessed repeatedly up to the age of 16 months (C57) or 23 months (CBA). Both strains of mice exposed to toluene at 1 month of age showed a mild loss of sensitivity at a high frequency (31.5 kHz) shortly after exposure. With increasing age, toluene exposure had little effect on the aging process of the auditory system in CBA mice but accelerated age-related hearing loss in C57 mice. The results indicate that toluene exposure can aggravate auditory deterioration only in mice with a strong genetic predisposition to spontaneously precocious age-related hearing loss.
两种近交系小鼠，CBA/Ca（生命后期开始出现中度听力损失）和C57BL/6J（自发性听觉退化发病较早），在1月龄或6月龄时通过吸入方式暴露于甲苯（1000 ppm，每天12小时，共7天）。在暴露后3 - 5天测量听觉脑干反应（ABR）阈值，并在16月龄（C57）或23月龄（CBA）之前反复评估。1月龄时暴露于甲苯的两种品系小鼠在暴露后不久均在高频（31.5 kHz）出现轻度敏感性丧失。随着年龄增长，甲苯暴露对CBA小鼠听觉系统的衰老过程影响不大，但加速了C57小鼠与年龄相关的听力损失。结果表明，甲苯暴露仅在具有强烈遗传易感性的自发性早熟年龄相关性听力损失小鼠中会加剧听觉退化。
