Wannamethee S G, Whincup P H, Rumley A, Lowe G D O
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK.
J Thromb Haemost. 2007 Aug;5(8):1637-43. doi: 10.1111/j.1538-7836.2007.02643.x. Epub 2007 Jun 1.
Interleukin-6 (IL-6) has been implicated in the development of cardiovascular disease. We have examined the relationship between plasma IL-6 and insulin resistance, and metabolic, inflammatory and hemostatic markers.
We examined 3490 men aged 60-79 years who were drawn from general practices in 24 British towns. The men were not diabetic and were not taking warfarin.
IL-6 was significantly associated with age, body mass index (BMI), waist circumference (WC), cigarette smoking, low physical activity, social class and alcohol intake (U-shaped). IL-6 showed no association with insulin resistance or its other components (blood glucose, triglycerides, blood pressure) except high-density lipoprotein-cholesterol (inversely), and no association with hematocrit, factor (F) VII or adiponectin after adjustment for age and WC. IL-6 was strongly associated with markers of inflammation (C-reactive protein, fibrinogen, white cell count); plasma viscosity; elevated markers of coagulation (fibrin D-dimer, FVIII, FIX); markers of endothelial dysfunction (von Willebrand factor, tissue plasminogen activator); and to a smaller extent with platelet count, APC ratio and gamma glutamyltransferase. Risk of the metabolic syndrome increased significantly with increasing IL-6 but was attenuated after adjustment for BMI.
IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease.
白细胞介素-6（IL-6）与心血管疾病的发生有关。我们研究了血浆IL-6与胰岛素抵抗、代谢、炎症及止血标志物之间的关系。
我们对来自英国24个城镇普通诊所的3490名60 - 79岁男性进行了研究。这些男性无糖尿病且未服用华法林。
IL-6与年龄、体重指数（BMI）、腰围（WC）、吸烟、低体力活动、社会阶层及酒精摄入量（呈U型关系）显著相关。除高密度脂蛋白胆固醇（呈负相关）外，IL-6与胰岛素抵抗或其其他成分（血糖、甘油三酯、血压）无关联，在调整年龄和WC后，与血细胞比容、因子（F）VII或脂联素也无关联。IL-6与炎症标志物（C反应蛋白、纤维蛋白原、白细胞计数）、血浆粘度、凝血标志物升高（纤维蛋白D - 二聚体、FVIII、FIX）、内皮功能障碍标志物（血管性血友病因子、组织型纤溶酶原激活剂）密切相关，与血小板计数、活化部分凝血活酶时间比值及γ-谷氨酰转移酶的相关性较小。代谢综合征的风险随IL-6升高而显著增加，但在调整BMI后减弱。
IL-6可能在心血管危险因素与心血管疾病的多种生物学机制之间起潜在的中介作用。
