Selvakumar D, Vijayasamundeeswari C K, Sendhav Sandip, Ekambaram Gnanadesigan
Bioinformation. 2022 Aug 31;18(8):675-682. doi: 10.6026/97320630018675. eCollection 2022.
Serum levels of inflammatory cytokines such as IL-6, high-sensitivity C-reactive protein as well as uric acids have been considered as predictors of severe outcomes in patients with coronary artery disease (CAD) associated with hypertension (HTN) and Type 2 Diabetes Mellitus (T2DM). Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. The evaluated high levels of inflammatory cytokines and uric acids in hypertensive CAD patients with diabetes might be helpful in the diagnosis of patients at greater risk.
血清炎症细胞因子水平，如白细胞介素-6、高敏C反应蛋白以及尿酸，已被视为患有与高血压（HTN）和2型糖尿病（T2DM）相关的冠状动脉疾病（CAD）患者严重预后的预测指标。记录了80例高血压、患有和未患有2型糖尿病的冠状动脉疾病患者的人体测量参数并测量了主要危险因素水平，同时纳入了40名健康对照者。通过将研究对象分为3组进行比较，即：第一组：对照组（n = 40）；第二组：高血压、无2型糖尿病的CAD患者（n = 40）；第三组：高血压、有2型糖尿病的CAD患者（n = 40）。与无糖尿病组相比，2型糖尿病CAD组患者的体重指数、体重、收缩压、舒张压值更高。数据显示白细胞介素-6、高敏C反应蛋白和尿酸浓度之间呈正相关，且具有统计学意义。对患有糖尿病的高血压CAD患者中炎症细胞因子和尿酸的高水平评估可能有助于诊断高危患者。
