García-Closas Reina, García-Closas Montserrat, Kogevinas Manolis, Malats Núria, Silverman Debra, Serra Consol, Tardón Adonina, Carrato Alfredo, Castaño-Vinyals Gemma, Dosemeci Mustafa, Moore Lee, Rothman Nathaniel, Sinha Rashmi
Research Unit, University Hospital of Canary Islands, La Laguna, Tenerife, Spain.
Eur J Cancer. 2007 Jul;43(11):1731-40. doi: 10.1016/j.ejca.2007.05.007. Epub 2007 Jun 26.
Fruit and vegetable intake has been linked to bladder cancer risk; however, evidence for other foods or specific dietary factors is inconclusive. The association between diet and bladder cancer risk was evaluated among 912 incident bladder cancer cases and 873 controls in Spain. Data were consistent with a reduced bladder cancer risk associated with high fruit intake; however, the association was significant only among current smokers (OR (95% CI) for 5th versus 1st quintile: 0.5 (0.3-0.9), p trend=0.009). Evaluation of food subgroups showed significant inverse associations with high intakes of berries, Liliaceae vegetables and yellow-orange vegetables. The latter association was stronger among individuals with the GSTM1 present than the null genotype (0.4 (0.2, 0.7) and 0.9 (0.6, 1.3), respectively; p for interaction=0.04). Meat or fish intake, their cooking methods or level of doneness, or heterocyclic amine intakes were not significantly associated with risk. Intake of folate, other B-vitamins (B12, B6, B2) and retinol was also associated with a reduced risk, the strongest associations being for vitamin B6 (0.6 (0.4, 0.8) p trend=0.0006) and retinol (0.6 (0.4-0.9) p trend=0.004). Our findings indicate that fruit and vegetable intake, as well as B-vitamin and retinol intake might be associated with a reduced bladder cancer risk.
水果和蔬菜的摄入量与膀胱癌风险相关；然而，关于其他食物或特定饮食因素的证据尚无定论。在西班牙的912例新发膀胱癌病例和873名对照中评估了饮食与膀胱癌风险之间的关联。数据表明，高水果摄入量与降低的膀胱癌风险相关；然而，这种关联仅在当前吸烟者中显著（第5分位数与第1分位数相比的OR（95%CI）：0.5（0.3 - 0.9），p趋势 = 0.009）。对食物亚组的评估显示，高摄入量的浆果、百合科蔬菜和黄橙色蔬菜与膀胱癌风险呈显著负相关。后一种关联在具有GSTM1基因的个体中比在无该基因型的个体中更强（分别为0.4（0.2，0.7）和0.9（0.6，1.3）；交互作用p = 0.
