• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Potassium channels and uterine function.钾通道与子宫功能。
Semin Cell Dev Biol. 2007 Jun;18(3):332-9. doi: 10.1016/j.semcdb.2007.05.008. Epub 2007 May 24.
2
Potassium channels in the human myometrium.人类子宫肌层中的钾通道。
Exp Physiol. 2001 Mar;86(2):255-64. doi: 10.1113/eph8602181.
3
Uterine Excitability and Ion Channels and Their Changes with Gestation and Hormonal Environment.子宫兴奋和离子通道及其随妊娠和激素环境的变化。
Annu Rev Physiol. 2021 Feb 10;83:331-357. doi: 10.1146/annurev-physiol-032420-035509. Epub 2020 Nov 6.
4
Participation of BKCa2+ and KATP potassium ion channels in the contractility of human term pregnant myometrium in in vitro conditions.BKCa2+和KATP钾离子通道在体外条件下对人足月妊娠子宫肌层收缩性的影响
J Obstet Gynaecol Res. 2011 Mar;37(3):215-21. doi: 10.1111/j.1447-0756.2010.01340.x. Epub 2011 Jan 27.
5
Kv7 and Kv11 channels in myometrial regulation.Kv7 和 Kv11 通道在子宫肌层调节中的作用。
Exp Physiol. 2014 Mar;99(3):503-9. doi: 10.1113/expphysiol.2013.075754. Epub 2013 Oct 11.
6
Relationship of ion channel activity to control of myometrial calcium.离子通道活性与子宫肌层钙调控的关系
J Soc Gynecol Investig. 2000 Jan-Feb;7(1):4-11. doi: 10.1016/s1071-5576(99)00051-9.
7
Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.拉伸激活的双孔钾通道在妊娠和分娩中人类子宫肌中的表达。
PLoS One. 2010 Aug 25;5(8):e12372. doi: 10.1371/journal.pone.0012372.
8
Oxytocin can regulate myometrial smooth muscle excitability by inhibiting the Na -activated K channel, Slo2.1.催产素可通过抑制 Na+激活的 K+通道 Slo2.1 来调节子宫平滑肌的兴奋性。
J Physiol. 2019 Jan;597(1):137-149. doi: 10.1113/JP276806. Epub 2018 Nov 22.
9
Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel.足月妊娠和双胎妊娠时子宫伸展延长引起的人子宫平滑肌收缩活动适应性降低。TREK-1 通道的作用。
Biochem Pharmacol. 2018 Jun;152:252-263. doi: 10.1016/j.bcp.2018.03.021. Epub 2018 Mar 22.
10
A systematic review of the uterine relaxant effect of potassium channel openers.钾通道开放剂对子宫松弛作用的系统评价。
Curr Drug Discov Technol. 2013 Dec;10(4):263-9. doi: 10.2174/15701638113109990002.

引用本文的文献

1
SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.妊娠期间小鼠子宫肌层平滑肌细胞中SLO2.1/NALCN功能复合体的活性
J Cell Physiol. 2025 Apr;240(4):e70024. doi: 10.1002/jcp.70024.
2
Mapping genetic susceptibility to spontaneous preterm birth: analysis of Utah pedigrees to find inherited genetic factors.绘制自发性早产的遗传易感性图谱：对犹他州家系进行分析以寻找遗传因素。
Am J Obstet Gynecol. 2025 Jun;232(6):557.e1-557.e10. doi: 10.1016/j.ajog.2024.11.027. Epub 2024 Dec 6.
3
SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.孕期小鼠子宫肌层平滑肌细胞中SLO2.1/NALCN功能复合体的活性
bioRxiv. 2025 Mar 9:2024.05.29.596465. doi: 10.1101/2024.05.29.596465.
4
Association of maternal mineral status with the risk of preterm birth: a retrospective cohort study.母亲矿物质状况与早产风险的关联：一项回顾性队列研究。
Front Nutr. 2024 May 10;11:1329720. doi: 10.3389/fnut.2024.1329720. eCollection 2024.
5
BKCa channels are involved in spontaneous and lipopolysaccharide-stimulated uterine contraction in late gestation mice†.大电导钙激活钾通道参与妊娠晚期小鼠的自发性和脂多糖刺激的子宫收缩†
Biol Reprod. 2024 Apr 11;110(4):798-807. doi: 10.1093/biolre/ioad174.
6
Multiple pregnancies, the myometrium and the role of mechanical factors in the timing of labour.多胎妊娠、子宫肌层以及机械因素在分娩时机中的作用。
Curr Res Physiol. 2023 Aug 24;6:100105. doi: 10.1016/j.crphys.2023.100105. eCollection 2023.
7
Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.基于全基因组关联研究的妊娠期和自发性早产的荟萃分析确定了新的母体风险位点。
PLoS Genet. 2023 Oct 23;19(10):e1010982. doi: 10.1371/journal.pgen.1010982. eCollection 2023 Oct.
8
Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study.印度女性自发性早产相关的基因变异：一项前瞻性队列研究。
Lancet Reg Health Southeast Asia. 2023 Apr 18;14:100190. doi: 10.1016/j.lansea.2023.100190. eCollection 2023 Jul.
9
A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment.子宫内膜异位症的终身影响：发病机制与药物治疗。
Int J Mol Sci. 2023 Apr 19;24(8):7503. doi: 10.3390/ijms24087503.
10
Genes, exposures, and interactions on preterm birth risk: an exploratory study in an Argentine population.早产风险中的基因、暴露因素及相互作用：一项针对阿根廷人群的探索性研究。
J Community Genet. 2022 Dec;13(6):557-565. doi: 10.1007/s12687-022-00605-z. Epub 2022 Aug 17.

本文引用的文献

1
Myometrial expression of small conductance Ca2+-activated K+ channels depresses phasic uterine contraction.小电导钙激活钾通道的子宫肌层表达可抑制子宫的阶段性收缩。
Am J Physiol Cell Physiol. 2007 Feb;292(2):C832-40. doi: 10.1152/ajpcell.00268.2006.
2
KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.KCNE3是Kv4.3钾通道的一个抑制性亚基。
Biochem Biophys Res Commun. 2006 Aug 4;346(3):958-67. doi: 10.1016/j.bbrc.2006.06.004. Epub 2006 Jun 9.
3
Translocation of an endoproteolytically cleaved maxi-K channel isoform: mechanisms to induce human myometrial cell repolarization.一种经内蛋白水解切割的大电导钙激活钾通道亚型的易位：诱导人子宫肌层细胞复极化的机制。
J Physiol. 2006 Jun 1;573(Pt 2):329-41. doi: 10.1113/jphysiol.2006.106922. Epub 2006 Mar 9.
4
Physiological roles of ATP-sensitive K+ channels in smooth muscle.ATP敏感性钾通道在平滑肌中的生理作用。
J Physiol. 2006 May 1;572(Pt 3):617-24. doi: 10.1113/jphysiol.2006.105973.
5
Gestational change of K+ channel opener effect is correlated with the expression of uterine KATP channel subunits.钾离子通道开放剂作用的孕期变化与子宫ATP敏感性钾通道亚基的表达相关。
Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):49-56. doi: 10.1016/j.ejogrb.2004.11.026.
6
Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy.雌激素、孕激素和妊娠对Slo通道基因的可变剪接编程。
FEBS Lett. 2005 Aug 29;579(21):4856-60. doi: 10.1016/j.febslet.2005.07.069.
7
Functional coupling of beta3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes.人子宫肌细胞中β3-肾上腺素能受体与大电导钙激活钾通道的功能偶联
J Clin Endocrinol Metab. 2005 Oct;90(10):5786-96. doi: 10.1210/jc.2005-0574. Epub 2005 Jul 12.
8
Expression of TASK and TREK, two-pore domain K+ channels, in human myometrium.双孔域钾通道TASK和TREK在人子宫肌层中的表达。
Reproduction. 2005 Apr;129(4):525-30. doi: 10.1530/rep.1.00442.
9
Calcium-activated chloride channels.钙激活氯离子通道
Annu Rev Physiol. 2005;67:719-58. doi: 10.1146/annurev.physiol.67.032003.154341.
10
Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current.大电导钙激活钾通道（Maxi-K通道）定位于人子宫肌层的小窝：肌动蛋白-通道-小窝蛋白复合物在调节子宫肌层平滑肌钾离子电流中的作用。
Am J Physiol Cell Physiol. 2005 Jul;289(1):C49-57. doi: 10.1152/ajpcell.00399.2004. Epub 2005 Feb 9.

钾通道与子宫功能。

Potassium channels and uterine function.

作者信息

Brainard Adam M, Korovkina Victoria P, England Sarah K

机构信息

University of Iowa Carver College of Medicine, Department of Molecular Physiology and Biophysics, Iowa City, IA 52242, United States.

出版信息

Semin Cell Dev Biol. 2007 Jun;18(3):332-9. doi: 10.1016/j.semcdb.2007.05.008. Epub 2007 May 24.

DOI:10.1016/j.semcdb.2007.05.008
PMID:17596977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2012947/
Abstract

Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in maintaining a normal gestational period and initiating labor contractions at term.

摘要

离子通道是在整个妊娠期介导子宫兴奋性的效应蛋白。本综述将主要关注钾通道在调节妊娠期间子宫肌层张力和分娩宫缩中的作用。在妊娠期，钾通道通过维持静息膜电位并抵消收缩刺激，使子宫保持在静息状态。本综述总结了目前关于钾通道在维持正常妊娠期和足月引发分娩宫缩方面意义的知识。