Hong Sumiao, Jiang Nan, Lin Guankai, Wang Quqing, Xu Xiaoyang, Shi Xinrui, Zhou You, Wen Xiaoting, Sun Baochang, Wang Hexing, Huang Min, Wang Jiwei, Wang Na, Chen Yue, Jiang Qingwu
Department of the Obstetrics, The People's Hospital of Pingyang, Wenzhou, China.
Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health, Fudan University, Shanghai, China.
Front Nutr. 2024 May 10;11:1329720. doi: 10.3389/fnut.2024.1329720. eCollection 2024.
There has been a gradual increase in the proportion of preterm birth in China during the past several decades. Maternal malnutrition is a significant determinant for preterm birth. Nevertheless, comprehensive studies investigating serum mineral levels during pregnancy associated with preterm birth remain scarce. This study aims to assess the associations between maternal serum mineral levels and the risk of preterm birth.
This retrospective cohort study of 18,048 pregnant women used data from a tertiary hospital in China from January 2016 to December 2022. Demographic data and serum mineral concentrations in the second and third trimesters of mothers were collected from the hospital information system. Analysis was performed using restricted cubic splines and logistic regression models.
The proportion of preterm birth in this study was 6.01%. Phosphorus [P for overall = 0.005; P for nonlinear = 0.490; OR (95%CI) = 1.11 (1.04, 1.18)] and chlorine [P for overall = 0.002; P for nonlinear = 0.058; OR (95%CI) = 1.11 (1.03, 1.19)] showed a significant positive correlation with preterm birth in a linear fashion. Furthermore, serum levels of potassium (P for nonlinear <0.001), sodium (P for nonlinear = 0.004), and magnesium (P for nonlinear <0.001) exhibited non-linear relationships with the risk of preterm birth.
Serum levels of some minerals during pregnancy were associated with the risk of preterm birth among pregnant women. In addition to commonly recognized micronutrients such as folic acid, iron, and vitamin D, healthcare providers should also pay attention to the levels of these minerals during pregnancy.
在过去几十年中，中国早产的比例逐渐上升。孕产妇营养不良是早产的一个重要决定因素。然而，关于孕期血清矿物质水平与早产相关性的综合研究仍然很少。本研究旨在评估孕产妇血清矿物质水平与早产风险之间的关联。
这项对18,048名孕妇的回顾性队列研究使用了中国一家三级医院2016年1月至2022年12月的数据。从医院信息系统收集母亲孕中期和孕晚期的人口统计学数据和血清矿物质浓度。使用受限立方样条和逻辑回归模型进行分析。
本研究中早产的比例为6.01%。磷[总体P = 0.005；非线性P = 0.490；OR(95%CI)= 1.11(1.04, 1.18)]和氯[总体P = 0.002；非线性P = 0.058；OR(95%CI)= 1.11(1.03, 1.19)]与早产呈显著正线性相关。此外，血清钾水平（非线性P <0.001）、钠水平（非线性P = 0.004）和镁水平（非线性P <0.001）与早产风险呈非线性关系。
孕期某些矿物质水平与孕妇早产风险相关。除了叶酸、铁和维生素D等常见的微量营养素外，医疗保健提供者在孕期也应关注这些矿物质的水平。
