Hantooshzadeh Sedigheh, Rezaeizadeh Golnaz, Nikfar Shekoufeh, Ghiasi Sima, Abdollahi Mohammad
Faculty of Pharmacy and Pharmaceutical Sciences Research Center, TUMS, Tehran 1417614411, Iran.
Curr Drug Discov Technol. 2013 Dec;10(4):263-9. doi: 10.2174/15701638113109990002.
Despite significant advances in the understanding of uterine physiology, preterm labor is still a predicament with a high incidence. The mechanism that triggers uterine contraction is currently unclear. ATP-sensitive potassium (KATP) channel stimulation has an inhibitory effect on uterine contractile pursuit through hyperpolarization of myometrial cells where KATP channels openers (KCOs) act as a tocolytic. In this review, studies that report the effects of KCOs on the contractile activity of the myometrium have been collected and evaluated. All electronic databases were searched up to 1(st)December 2012 with the most relevant keywords. Studies related to the effect of KCOs on the human or animal myometrium both in vivo and in vitro were included. Of initial search, 45 records were reviewed and finally, 23 were included. All of these studies found that KCOs have an inhibitory effect on the myometrium contractions, but different sample size and inconsistencies in reporting the effects make the absolute judgment about efficacy of these compounds too difficult. Of course, we can state that the inhibitory effects of KCOs were greater in myometrium of non-labor group. Conclusion is that although some positive effects are expected, yet further placebo-controlled studies are needed to reach a consensus.
尽管在子宫生理学的理解方面取得了重大进展，但早产仍然是一种高发病率的困境。目前尚不清楚触发子宫收缩的机制。ATP敏感性钾（KATP）通道刺激通过使子宫肌层细胞超极化而对子宫收缩活动产生抑制作用，其中KATP通道开放剂（KCOs）起到宫缩抑制剂的作用。在这篇综述中，收集并评估了报告KCOs对子宫肌层收缩活动影响的研究。使用最相关的关键词在所有电子数据库中检索至2012年12月1日。纳入了与KCOs对人和动物子宫肌层在体内和体外的影响相关的研究。在初步检索中，审查了45条记录，最终纳入23条。所有这些研究都发现KCOs对子宫肌层收缩有抑制作用，但不同的样本量以及在报告效果方面的不一致使得对这些化合物疗效做出绝对判断过于困难。当然，我们可以指出KCOs在未临产组的子宫肌层中的抑制作用更大。结论是，尽管预期会有一些积极效果，但仍需要进一步的安慰剂对照研究以达成共识。
