Scaria Joy, Chandramouli Umamaheswaran, Verma Sanjay Kumar
Center for Biotechnology, Biological Sciences Group, Birla Institute of Technology & Science, Pilani-333031, India.
Bioinformation. 2005 Mar 17;1(1):5-7. doi: 10.6026/97320630001005.
Vancomycin and beta-lactams are antibiotics that inhibit gram positive bacteria by interfering with cell wall synthesis. However, continuous use of antibiotics results in the emergence of multi-drug resistant (MDR) bacterial strains. Here, we describe ARGO, a database containing gene sequences conferring resistance to these two classes of antibiotics. It is designed as a resource to enhance research on the prevalence and spread of antibiotic resistance genes. ARGO is the first attempt to compile the resistance gene sequence data with state specific information.
AGRO is available for free at http://www.argodb.org/
万古霉素和β-内酰胺类抗生素通过干扰细胞壁合成来抑制革兰氏阳性菌。然而,抗生素的持续使用导致了多重耐药(MDR)菌株的出现。在此,我们描述了ARGO,一个包含赋予对这两类抗生素耐药性的基因序列的数据库。它被设计为一种资源,以加强对抗生素耐药基因的流行和传播的研究。ARGO是首次尝试汇编带有州特定信息的耐药基因序列数据。