Nilsen Arvid, Kasubi Mabula Joseph, Mohn Stein Christian, Mwakagile Davis, Langeland Nina, Haarr Lars
Department of Dermatology, Institute of Medicine, University of Bergen, Bergen, Norway.
Acta Derm Venereol. 2007;87(4):355-9. doi: 10.2340/00015555-0241.
The relative importance of Haemophilus ducreyi and Treponema pallidum in genital ulcer disease in Africa has decreased recently, whereas that of herpes simplex virus (HSV) type 2 has increased. We analysed 301 lesional specimens from Tanzanian patients with genital ulcer disease for the presence of H. ducreyi, T. pallidum and HSV-1/HSV-2 by performing a separate PCR for each pathogen. Infectious agents were detected in 211 (70%) of the cases. A single pathogen was found in 191 samples and two or more pathogens in the remaining 20. HSV-2 represented 83% of all identified pathogens, HSV-1 8%, T. pallidum 4% and H. ducreyi 5%. HSV-1 was identified as a single pathogen in four samples, in combination with others in an additional 14 samples. Thus, HSV-1 can also be the cause of genital ulcer disease in Africa. Regular surveillance of genital ulcer disease aetiology is important in programs for management of genital ulcer disease and HIV in Africa.
在非洲，杜克嗜血杆菌和梅毒螺旋体在生殖器溃疡疾病中的相对重要性近来有所下降，而2型单纯疱疹病毒（HSV）的重要性则有所上升。我们通过针对每种病原体分别进行聚合酶链反应（PCR），分析了301份来自坦桑尼亚生殖器溃疡疾病患者的病变标本，以检测是否存在杜克嗜血杆菌、梅毒螺旋体以及HSV-1/HSV-2。在211例（70%）病例中检测到了感染病原体。191份样本中发现了单一病原体，其余20份样本中发现了两种或更多种病原体。HSV-2占所有已鉴定病原体的83%，HSV-1占8%，梅毒螺旋体占4%，杜克嗜血杆菌占5%。HSV-1在4份样本中被鉴定为单一病原体，在另外14份样本中与其他病原体同时存在。因此，HSV-1也可能是非洲生殖器溃疡疾病的病因。在非洲生殖器溃疡疾病和艾滋病管理项目中，定期监测生殖器溃疡疾病的病因很重要。
