Identification of a new sesquiterpene polyol ester from Celastrus paniculatus.

A new sesquiterpene polyol ester characterized as 1alpha,6beta,8beta-triacetoxy-9beta-benzoyloxydihydro-beta-agarofuran (1), along with the three known compounds: 1alpha,6beta,8alpha-triacetoxy-9alpha-benzoyloxydihydro-beta-agarofuran (2), angulatueoid C (3), and 1alpha,6beta,8beta,14-tetraacetoxy-9alpha-benzoyloxydihydro-beta-agarofuran (4), was isolated from the CCl (4)-soluble fraction of Celastrus paniculatus methanolic seed extract. All four compounds produce at a concentration of 1 microg/mL a relaxant effect on the isolated rat ileum of 31.4 +/- 7.5, 24.3 +/- 9.6, 24.4 +/- 4.9, and 16.2 +/- 7.2 %, respectively.