从苦皮藤中分离出的五种新型杀虫倍半萜类化合物。

Five new insecticidal sesquiterpenoids from Celastrus angulatus.

作者信息

Wu W, Wang M, Zhu J, Zhou W, Hu Z, Ji Z

机构信息

Department of Plant Protection, Northwestern Agricultural University, Shaanxi 712100, People's Republic of China.

出版信息

J Nat Prod. 2001 Mar;64(3):364-7. doi: 10.1021/np0004193.

DOI:10.1021/np0004193

PMID:11277758

Abstract

Five new sesquiterpene polyol esters were isolated from the root bark of Celastrus angulatus by bioassay-guided fractionation. Their structures were determined by spectral data interpretation as 1alpha,2alpha,6beta,8beta,13-pentaacetoxy-9beta-benzoyloxy-4beta-hydroxy-beta-dihydroagarofuran (1), 1alpha,2alpha,6beta-triacetoxy-8alpha-(beta-furancarbonyloxy)-9beta-benzoyloxy-13-isobutanoyloxy-4beta-hydroxy-beta-dihydroagarofuran (2), 1alpha,2alpha,6beta-triacetoxy-8beta-isobutanoyloxy-9beta-(beta-furancarbonyloxy)-13-(alpha-methyl)butanoyloxy-4beta-hydroxy-beta-dihydroagarofuran (3), 1alpha,2alpha,6beta-triacetoxy-8alpha,13-diisobutanoyloxy-9beta-benzoyloxy-4beta-hydroxy-beta-dihydroagarofuran (4), and 1alpha,2alpha,6beta-triacetoxy-8alpha-isobutanoyloxy-9beta-benzoyloxy-13-(alpha-methyl)butanoyloxy-4beta-hydroxy-beta-dihydroagarofuran (5). Compounds 1-5 exhibited insecticidal activity against the larval of Mythimna separata.

摘要

通过生物活性导向分离从苦皮藤根皮中分离出5种新的倍半萜多元醇酯。通过光谱数据分析确定它们的结构分别为1α,2α,6β,8β,13-五乙酰氧基-9β-苯甲酰氧基-4β-羟基-β-二氢沉香呋喃（1）、1α,2α,6β-三乙酰氧基-8α-（β-呋喃甲酰氧基）-9β-苯甲酰氧基-13-异丁酰氧基-4β-羟基-β-二氢沉香呋喃（2）、1α,2α,6β-三乙酰氧基-8β-异丁酰氧基-9β-（β-呋喃甲酰氧基）-13-（α-甲基）丁酰氧基-4β-羟基-β-二氢沉香呋喃（3）、1α,2α,6β-三乙酰氧基-8α,13-二异丁酰氧基-9β-苯甲酰氧基-4β-羟基-β-二氢沉香呋喃（4）和1α,2α,6β-三乙酰氧基-8α-异丁酰氧基-9β-苯甲酰氧基-13-（α-甲基）丁酰氧基-4β-羟基-β-二氢沉香呋喃（5）。化合物1-5对粘虫幼虫表现出杀虫活性。