Winger David I, Spiegler Peter, Trow Terence K, Goyal Amit, Yu Huiying, Yung Elizabeth, Katz Douglas S
Department of Radiology, Winthrop-University Hospital, Mineola, NY, 11501, USA.
Clin Imaging. 2007 Jul-Aug;31(4):264-8. doi: 10.1016/j.clinimag.2007.03.007.
Pulmonary hyalinizing granulomata are rare, noninfectious, fibrosing lesions of the lung, which can mimic metastatic disease radiographically. Their etiology is unknown, but they may be caused by an exaggerated immune response. We report the radiology, long clinical course, and pathology of a patient with pulmonary hyalinizing granuloma who presented with initially asymptomatic pulmonary nodules. Over a 10-year period, the patient developed multiple insidious autoimmune phenomena, including lupus anticoagulant, neuromyotonia, demyelinating sensorimotor polyneuropathy, and eventually, Morvan's syndrome. Such an association has not been previously published to our knowledge.
