Thoman Maxton E, McKarns Susan C
Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Laboratory of TGF-β Biology, Epigenetics, and Cytokine Regulation, Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Metabolites. 2020 Sep 18;10(9):374. doi: 10.3390/metabo10090374.
There is no specific test for diagnosing neuromyelitis optica spectrum disorder (NMOSD), a disabling autoimmune disease of the central nervous system. Instead, diagnosis relies on ruling out other related disorders with overlapping clinical symptoms. An urgency for NMOSD biomarker discovery is underscored by adverse responses to treatment following misdiagnosis and poor prognosis following the delayed onset of treatment. Pathogenic autoantibiotics that target the water channel aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) contribute to NMOSD pathology. The importance of early diagnosis between AQP4-Ab NMOSD, MOG-Ab NMOSD, AQP4-Ab MOG-Ab NMOSD, and related disorders cannot be overemphasized. Here, we provide a comprehensive data collection and analysis of the currently known metabolomic perturbations and related proteomic outcomes of NMOSD. We highlight short chain fatty acids, lipoproteins, amino acids, and lactate as candidate diagnostic biomarkers. Although the application of metabolomic profiling to individual NMOSD patient care shows promise, more research is needed.
视神经脊髓炎谱系障碍（NMOSD）是一种使中枢神经系统致残的自身免疫性疾病，目前尚无用于诊断该病的特异性检测方法。相反，诊断依赖于排除其他具有重叠临床症状的相关疾病。误诊后治疗的不良反应以及治疗延迟导致的不良预后凸显了发现NMOSD生物标志物的紧迫性。靶向水通道蛋白4（AQP4）和髓鞘少突胶质细胞糖蛋白（MOG）的致病性自身抗体导致了NMOSD的病理过程。早期诊断AQP4抗体阳性NMOSD、MOG抗体阳性NMOSD、AQP4抗体和MOG抗体均阳性的NMOSD以及相关疾病的重要性无论如何强调都不为过。在此，我们提供了一份关于NMOSD目前已知的代谢组学扰动和相关蛋白质组学结果的全面数据收集与分析。我们将短链脂肪酸、脂蛋白、氨基酸和乳酸作为候选诊断生物标志物进行了重点介绍。尽管代谢组学分析应用于个体NMOSD患者护理显示出前景，但仍需要更多研究。
