Stankiewicz James, Panter S Scott, Neema Mohit, Arora Ashish, Batt Courtney E, Bakshi Rohit
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Neurotherapeutics. 2007 Jul;4(3):371-86. doi: 10.1016/j.nurt.2007.05.006.
Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurological disorders including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood. It is not known whether excessive in vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article, we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.
铁对于脑氧运输、电子传递、神经递质合成及髓鞘生成至关重要。尽管在正常衰老过程中已观察到脑内有铁沉积，但在包括阿尔茨海默病、帕金森病和多发性硬化症在内的许多慢性神经疾病中，铁含量也有所增加。体外研究表明，过量的铁可导致自由基产生，进而促进神经毒性。然而，脑内观察到的铁沉积与各种脑部疾病潜在病理过程之间的联系尚未完全明确。体内铁过量是直接导致组织损伤还是仅仅是一种附带现象尚不清楚。在本文中，我们聚焦于脑铁成像以及与铁沉积相关的基础生理学和代谢。最后，我们讨论了铁相关毒性对神经治疗发展的潜在影响。
