Andrei Anna Maria, Fraguas Renerio, Telles Renata M S, Alves Tânia C T F, Strunz Celia M C, Nussbacher Amit, Rays Jairo, Iosifescu Dan V, Wajngarten Mauricio
Heart Institute, University of São Paulo School of Medicine, São Paulo, SP, Brazil.
Psychosomatics. 2007 Jul-Aug;48(4):319-24. doi: 10.1176/appi.psy.48.4.319.
The authors evaluated levels of inflammatory markers in 34 chronic heart failure (CHF) out-patients age 65 years and over, with (N=18) and without (N=16) major depressive disorder (MDD), and healthy-control subjects (N=13). Patients with CHF had left-ventricular ejection fractions <0.40 and were in the New York Heart Association functional class II or III. The authors used the SCID DSM-IV to diagnosis MDD. High-sensitivity C-reactive protein levels were significantly higher in patients with CHF and MDD as compared with healthy-control subjects. No differences regarding tumor necrosis factor(alpha) or interleukin(6) were found among the three groups.
作者评估了34名65岁及以上的慢性心力衰竭（CHF）门诊患者的炎症标志物水平，其中18名患有重度抑郁症（MDD），16名未患MDD，另有13名健康对照者。CHF患者的左心室射血分数<0.40，纽约心脏协会心功能分级为II级或III级。作者使用《精神疾病诊断与统计手册第四版》结构化临床访谈来诊断MDD。与健康对照者相比，CHF合并MDD患者的高敏C反应蛋白水平显著更高。三组之间在肿瘤坏死因子（α）或白细胞介素（6）方面未发现差异。
