Reitz Christiane, Berger Klaus, de Maat Moniek P M, Stoll Monika, Friedrichs Frauke, Kardys Isabella, Witteman Jacqueline C M, Breteler Monique M B
Stroke. 2007 Aug;38(8):2356-9. doi: 10.1161/STROKEAHA.107.482661. Epub 2007 Jun 28.
It remains unclear whether C-reactive protein (CRP) is a serum marker for atherothrombotic disease or a causal factor in the pathogenesis of atherosclerosis. We explored the association between CRP gene variations and cerebral small-vessel disease (SVD) in the Rotterdam Scan Study (N=1035) and the MEMO Study (N=268).
Common haplotypes within the CRP gene were determined by genotype-tagging single-nucleotide polymorphisms. Then their relation with periventricular and subcortical white matter lesions and the prevalence of lacunar brain infarcts was explored by regression analyses.
There was no association between CRP haplotypes and measures of cerebral SVD in either study. There was no effect modification of the association between serum CRP levels and measures of SVD by CRP haplotypes.
Our observations suggest that CRP is not causally involved in the pathogenesis of SVD.
目前尚不清楚C反应蛋白（CRP）是动脉粥样硬化血栓形成疾病的血清标志物还是动脉粥样硬化发病机制中的致病因素。在鹿特丹扫描研究（N = 1035）和MEMO研究（N = 268）中，我们探讨了CRP基因变异与脑小血管疾病（SVD）之间的关联。
通过基因型标签单核苷酸多态性确定CRP基因内的常见单倍型。然后通过回归分析探讨它们与脑室周围和皮质下白质病变以及腔隙性脑梗死患病率的关系。
两项研究中CRP单倍型与脑SVD指标之间均无关联。CRP单倍型对血清CRP水平与SVD指标之间的关联没有效应修正作用。
我们的观察结果表明CRP与SVD的发病机制无因果关系。
