Maberry M C, Gilstrap L C, Bawdon R, Little B B, Dax J
Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
Am J Perinatol. 1991 Sep;8(5):338-41. doi: 10.1055/s-2007-999409.
Although intrapartum antibiotics are beneficial to both the mother and newborn, there is no consensus as to the most efficacious antibiotic regimen in the treatment of intra-amnionic infection, especially with regard to anaerobic coverage. We randomized pregnant women with intra-amnionic infection to receive either dual agent therapy (ampicillin and gentamicin) or triple agent therapy (ampicillin, gentamicin, and clindamycin). The frequency of vaginal and cesarean delivery was similar in both groups. There was no significant difference in the incidence of endometritis between the two groups (10 of 69 versus 5 of 64; p = NS). There were no significant differences in either neonatal morbidity or mortality. The addition of clindamycin to provide anaerobic coverage for intra-amnionic infection does not significantly alter the incidence of endometritis in women delivered by cesarean section, although it may have an impact on women delivering vaginally.
尽管产时使用抗生素对母亲和新生儿都有益，但对于治疗羊膜腔内感染的最有效抗生素方案，尤其是在厌氧菌覆盖方面，尚无共识。我们将患有羊膜腔内感染的孕妇随机分为两组，分别接受双联疗法（氨苄西林和庆大霉素）或三联疗法（氨苄西林、庆大霉素和克林霉素）。两组的阴道分娩和剖宫产频率相似。两组之间子宫内膜炎的发生率无显著差异（69例中有10例，64例中有5例；p值无统计学意义）。新生儿发病率或死亡率均无显著差异。虽然添加克林霉素以覆盖羊膜腔内感染的厌氧菌可能对经阴道分娩的女性有影响，但对于剖宫产分娩的女性，添加克林霉素并不会显著改变子宫内膜炎的发生率。
