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Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.

作者信息

Harki Daniel A, Graci Jason D, Edathil Jocelyn P, Castro Christian, Cameron Craig E, Peterson Blake R

机构信息

Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802, USA.

出版信息

Chembiochem. 2007 Aug 13;8(12):1359-62. doi: 10.1002/cbic.200700160.

DOI:10.1002/cbic.200700160
PMID:17600792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2194811/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/f88dac3222d5/nihms34064f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/b19d2e113994/nihms34064f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/c1f1aa146f0a/nihms34064f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/22b37f45dd7e/nihms34064f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/0dea644097e5/nihms34064f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/b46606336ff1/nihms34064f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/f88dac3222d5/nihms34064f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/b19d2e113994/nihms34064f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/c1f1aa146f0a/nihms34064f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/22b37f45dd7e/nihms34064f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/0dea644097e5/nihms34064f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/b46606336ff1/nihms34064f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/288e/2194811/f88dac3222d5/nihms34064f6.jpg

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本文引用的文献

1
Solution structure and dynamics of DNA duplexes containing the universal base analogues 5-nitroindole and 5-nitroindole 3-carboxamide.含有通用碱基类似物5-硝基吲哚和5-硝基吲哚-3-甲酰胺的DNA双链体的溶液结构与动力学
Nucleic Acids Res. 2007;35(9):2904-12. doi: 10.1093/nar/gkm074. Epub 2007 Apr 16.
2
Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.利巴韦林与脊髓灰质炎病毒的致死性诱变：分子机制、抗性及生物学意义
Virus Res. 2005 Feb;107(2):173-81. doi: 10.1016/j.virusres.2004.11.007.
3
Viral error catastrophe by mutagenic nucleosides.诱变核苷导致的病毒错误灾难
Annu Rev Microbiol. 2004;58:183-205. doi: 10.1146/annurev.micro.58.030603.123649.
4
Improved allelic differentiation using sequence-specific oligonucleotide hybridization incorporating an additional base-analogue mismatch.使用包含额外碱基类似物错配的序列特异性寡核苷酸杂交改进等位基因分化。
Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):755-65. doi: 10.1081/NCN-120039216.
5
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+.脊髓灰质炎病毒RNA依赖的RNA聚合酶（3Dpol）：在存在Mn2+的情况下核糖核苷酸掺入的预稳态动力学分析
Biochemistry. 2004 May 11;43(18):5138-48. doi: 10.1021/bi035213q.
6
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Biochemistry. 2004 May 11;43(18):5126-37. doi: 10.1021/bi035212y.
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Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?致死性诱变剂：具有有限耐药性发展潜力的广谱抗病毒药物？
Drug Resist Updat. 2004 Feb;7(1):19-24. doi: 10.1016/j.drup.2003.12.003.
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Biochemistry. 2003 Sep 9;42(35):10472-81. doi: 10.1021/bi034763l.
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Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.一种诱变且无氢键核糖核苷类似物：1-β-D-呋喃核糖基-3-硝基吡咯的合成与抗病毒评估
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10
The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase.利巴韦林的作用机制：由病毒RNA依赖性RNA聚合酶介导的RNA病毒基因组的致死性诱变。
Curr Opin Infect Dis. 2001 Dec;14(6):757-64. doi: 10.1097/00001432-200112000-00015.