Lambrou Panagiota, Zervas Eleftherios, Oikonomidou Erasmia, Papageorgiou Niki, Alchanatis Manos, Gaga Mina
Department of Respiratory Medicine, Athens University Medical School, Athens, Greece.
Ann Allergy Asthma Immunol. 2007 Jun;98(6):567-72. doi: 10.1016/S1081-1206(10)60737-5.
Asthma and rhinitis often coexist, and there is evidence to suggest that they have similar histopathologic features.
To examine whether the inflammatory infiltration in the nasal mucosa in rhinitis is affected by the presence of asthma and allergy.
Nasal mucosa biopsy samples were collected from 44 individuals: 18 with rhinitis and asthma (9 allergic and 9 nonallergic), 16 with rhinitis and no asthma (8 allergic and 8 nonallergic), and 10 nonallergic control subjects. The alkaline phosphatase-anti-alkaline phosphatase method was applied to 6-microm-thick cryostat sections using monoclonal antibodies against T cells (CD4 and CD8) and eosinophils (EG2). Slides were counted blindly, and results are expressed as cells per high-power field.
Eosinophil counts were higher in the nasal mucosa of rhinitic patients vs controls. No differences in cellular infiltration were detected between rhinitic patients with and without asthma or between allergic and nonallergic patients. A trend toward higher CD4+ T-cell counts in the nasal mucosa of rhinitic patients was observed, whereas no differences were noted in CD8+ T-cell infiltration among the groups.
Inflammatory infiltration, characterized by the presence of eosinophils and CD4+ T cells, was similar in the nasal mucosa in noninfectious rhinitis irrespective of the presence of asthma or the allergic status of the patient.
哮喘和鼻炎常同时存在，且有证据表明它们具有相似的组织病理学特征。
研究鼻炎患者鼻黏膜中的炎性浸润是否受哮喘和过敏的影响。
收集了44例个体的鼻黏膜活检样本：18例患有鼻炎和哮喘（9例过敏，9例非过敏），16例患有鼻炎但无哮喘（8例过敏，8例非过敏），以及10例非过敏对照者。使用抗T细胞（CD4和CD8）和嗜酸性粒细胞（EG2）的单克隆抗体，对6微米厚的低温恒温器切片采用碱性磷酸酶-抗碱性磷酸酶法。对玻片进行盲法计数，结果以每高倍视野的细胞数表示。
鼻炎患者鼻黏膜中的嗜酸性粒细胞计数高于对照组。在有哮喘和无哮喘的鼻炎患者之间或过敏和非过敏患者之间，未检测到细胞浸润的差异。观察到鼻炎患者鼻黏膜中CD4 + T细胞计数有升高趋势，而各组间CD8 + T细胞浸润无差异。
无论患者是否患有哮喘或过敏状态如何，非感染性鼻炎鼻黏膜中以嗜酸性粒细胞和CD4 + T细胞存在为特征的炎性浸润相似。
