Parada David, Godoy All, Liuzzi Francisco, Pelia Karla B, Romero Aramis, Parada Arelí M
Department of Anatomic Pathology, Vargas Hospital, Caracas, Venezuela.
Arch Esp Urol. 2007 Apr;60(3):321-5. doi: 10.4321/s0004-06142007000300020.
Ewing's sarcoma/Primitive neuroectodermal tumor (ES/PNET) is an extraordinarily rare primary tumor in the kidney. We re-port herein the clinical, histological, and immunohisto-chemical features of a primary renal ES/PNET.
A 19-year old male referred a two weeks history of constant, colic, left flank pain, and fever. A left radical nephrectomy was performed. Gross pathologic examination showed pink-tan, lobulated solid tumor, localized at the superior pole.
Histologically, the tumor was solid with necrosis. The neoplastic cells showed a small amount of clear cytoplasm, and had vesicular nuclei with small nucleoli. Immunohistochemical studies showed strongly and diffusely positive staining for CD99 in a membranous pattern.
This case represents a typical ES/ PNET affecting a young male patient. Adequate diagnosis is important because this neoplasm has an aggressive behaviour.
尤因肉瘤/原始神经外胚层肿瘤（ES/PNET）是一种极其罕见的原发性肾脏肿瘤。我们在此报告一例原发性肾ES/PNET的临床、组织学和免疫组织化学特征。
一名19岁男性患者，有持续两周的绞痛性左腰痛和发热病史。行左肾根治性切除术。大体病理检查显示为粉红色至棕褐色、分叶状实性肿瘤，位于上极。
组织学上，肿瘤为实性伴坏死。肿瘤细胞胞质少量清亮，核呈泡状，核仁小。免疫组织化学研究显示CD99呈强弥漫性膜性阳性染色。
该病例代表了一例影响年轻男性患者的典型ES/PNET。由于这种肿瘤具有侵袭性，准确诊断很重要。
