Antiviral 1,3,4-thiadiazoles. II. Effects on cellular and viral RNA synthesis in Mengo-virus-infected FL cells.

Three antiviral 1,3,4-thiadiazoles caused, when incubated together with 3H-uridine, a reduction of the incorporation rate into acid-insoluble material of FL cells. Using the method of prelabelling cellular RNA synthesis was not remarkably influenced. However, the substances tested act as specific inhibitors of the virus-induced RNA synthesis.