Ward Wendy E, Fonseca Debbie
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mol Nutr Food Res. 2007 Jul;51(7):824-31. doi: 10.1002/mnfr.200600187.
Osteoporosis is a silent disease that leads to fragility fractures that can diminish quality of life and contribute to death. With no ideal drug treatment available to manage osteoporosis, soy isoflavones (ISO), and omega-3 long chain PUFAs in fish oil (FO) may be integral in a dietary strategy that prevents bone loss. The overall objective of this study was to determine if combining ISO with omega-3 long chain PUFAs resulted in greater protection against the loss of bone mineral and skeletal weakening in ovariectomized mice. Ovariectomized CD-1 mice were randomized to control diet or a diet containing ISO alone (250 mg of genistein + 250 mg of daidzein/kg diet), FO alone (7% menhaden oil), or ISO + FO. Each dietary intervention prevented the loss of bone mineral density (BMD) in the femur and preserved femur strength, but only FO, either alone or combined with ISO, resulted in a higher BMD of lumbar vertebra (LV). Most notably, FO + ISO resulted in a higher peak load of LV4, indicating that vertebra were more resistant to fracture. Whether a dietary strategy providing FO in combination with ISO attenuates bone loss in postmenopausal women awaits investigation.
骨质疏松症是一种隐匿性疾病，会导致脆性骨折，从而降低生活质量并导致死亡。由于目前尚无理想的药物治疗方法来管理骨质疏松症，大豆异黄酮（ISO）和鱼油（FO）中的ω-3长链多不饱和脂肪酸可能是预防骨质流失的饮食策略的重要组成部分。本研究的总体目标是确定ISO与ω-3长链多不饱和脂肪酸联合使用是否能为去卵巢小鼠提供更强的保护，防止骨矿物质流失和骨骼变弱。将去卵巢的CD-1小鼠随机分为对照组饮食或单独含有ISO（250毫克染料木黄酮+250毫克大豆苷元/千克饮食）、单独含有FO（7%鲱鱼油）或ISO+FO的饮食组。每种饮食干预都能防止股骨骨矿物质密度（BMD）的流失并保持股骨强度，但只有单独的FO或与ISO联合使用时，才会使腰椎（LV）的BMD更高。最值得注意的是，FO+ISO导致LV4的峰值负荷更高，表明椎骨对骨折的抵抗力更强。提供FO与ISO联合使用的饮食策略是否能减轻绝经后女性的骨质流失还有待研究。
