Division of Cardiovascular Disease Research, Department of Chronic Disease Converengence Research, Korea National Institute of Health, Cheongju, Chungbuk, Republic of Korea.
Department of Anatomy and Neurobiology, Gyeongsang National University, Jinju, Gyeongnam, Republic of Korea.
PLoS One. 2022 Jul 12;17(7):e0271291. doi: 10.1371/journal.pone.0271291. eCollection 2022.
Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with the risk for macrosomia, an offspring's adverse outcome, in a Korean pregnancy registry cohort (n = 4,542) enrolled between 2013 and 2017.
Binge drinking was defined as consuming ≥5 drinks on one occasion and ≥2 times a week, and a total 2,886 pregnant, included in the final statistical analysis, were divided into 3 groups: never, non-binge, and binge drinking.
The prevalence of macrosomia was higher in binge drinking before pregnancy than those with never or non-binge drinking (7.5% vs. 3.2% or 2.9%, p = 0.002). Multivariable logistic regression analysis demonstrated an independent association between macrosomia and prepregnancy binge drinking after adjusting for other confounders (adjusted odds ratio = 2.29; 95% CI, 1.08-4.86; p = 0.031). The model added binge drinking before pregnancy led to improvement of 10.6% (95% CI, 2.03-19.07; p = 0.0006) in discrimination from traditional risk prediction models.
Together, binge drinking before pregnancy might be an independent risk factor for developing macrosomia. Intensified intervention for drinking alcohol in women who are planning a pregnancy is important and may help prevent macrosomia.
众所周知，怀孕期间饮酒会对胎儿发育造成有害影响；然而，孕前饮酒的不良影响在很大程度上尚不清楚。我们在韩国妊娠登记队列（n=4542）中研究了孕前饮酒状况是否与巨大儿（一种后代不良结局）的风险相关，该队列于 2013 年至 2017 年期间招募。
狂饮定义为一次性饮酒≥5 杯且每周≥2 次，共有 2886 名孕妇被纳入最终的统计分析，分为 3 组：从不饮酒、非狂饮和狂饮。
与从不饮酒或非狂饮相比，孕前狂饮的巨大儿发生率更高（7.5%比 3.2%或 2.9%，p=0.002）。在调整其他混杂因素后，多变量逻辑回归分析显示，孕前狂饮与巨大儿之间存在独立关联（调整后的优势比=2.29；95%置信区间，1.08-4.86；p=0.031）。加入孕前狂饮后，该模型对传统风险预测模型的区分度提高了 10.6%（95%置信区间，2.03-19.07；p=0.0006）。
综上所述，孕前狂饮可能是发生巨大儿的独立危险因素。对计划怀孕的妇女进行饮酒干预非常重要，这可能有助于预防巨大儿的发生。
