Cheng Xiao-Guang, Yang Ding-Zhuo, Zhou Qi, Zhuo Tie-Jun, Zhang Hua-Chou, Xiang Jing, Wang Hong-Fu, Ou Ping-Zhong, Liu Jian-Li, Xu Ling, Huang Gong-Yi, Huang Qi-Ren, Barden Howard S, Weynand Linda S, Faulkner Ken G, Meng Xun-Wu
Ji Shui Tan Hospital, Beijing, China.
J Clin Densitom. 2007 Jul-Sep;10(3):276-84. doi: 10.1016/j.jocd.2007.05.004. Epub 2007 Jun 28.
Our study surveyed age-related bone mineral density (BMD), bone loss rate, and prevalence of osteoporosis in women at multiple research centers in China. Survey results were used to establish a BMD reference database for the diagnosis of osteoporosis in Chinese women nationwide. We used dual-energy X-ray absorptiometry bone densitometers to measure BMD at posteroanterior (PA) lumbar spine (L1-L4; n=8142) and proximal femur (n=7290) in female subjects of age 20-89 yr from Beijing, Shanghai, Guangzhou, Chengdu, Nanjing, and Jiaxing. A cubic regression-fitting model was used to describe the change of BMD with age at various skeletal sites. Peak BMD occurred between 30 and 34 yr of age for femur neck and total femur, and between 40 and 44 yr for spine and trochanter measurement sites. Young adult (YA) BMD values (mean and standard deviation [SD], calculated as the average BMD in the age range of 20-39, were 1.116+/-0.12, 0.927+/-0.12, 0.756+/-0.11, and 0.963+/-0.13 g/cm2 at PA spine, femoral neck, trochanter, and total femur, respectively. The BMD of 85-yr-old women reflected a loss of 32% at the spine and 30-35% at femur measurement sites. The prevalence of osteoporosis, defined as a BMD of <or=-2.5 SDs from YA values established in this study, in female subjects of age 50 yr or older, was 28% for the spine, 15% for any femur site, and 31% for any spine or femur site. This study provides important information for formulating osteoporosis prevention and treatment strategies in Chinese women, and it establishes a reliable BMD reference database for the diagnosis of osteoporosis of Chinese women nationwide.
我们的研究对中国多个研究中心的女性进行了与年龄相关的骨密度（BMD）、骨质流失率和骨质疏松症患病率的调查。调查结果用于建立一个BMD参考数据库，以用于全国范围内中国女性骨质疏松症的诊断。我们使用双能X线吸收法骨密度仪，对来自北京、上海、广州、成都、南京和嘉兴的20至89岁女性受试者的后前位（PA）腰椎（L1-L4；n=8142）和股骨近端（n=7290）进行骨密度测量。采用三次回归拟合模型描述不同骨骼部位骨密度随年龄的变化。股骨颈和全股骨的峰值骨密度出现在30至34岁之间，脊柱和转子测量部位的峰值骨密度出现在40至44岁之间。年轻成人（YA）的骨密度值（均值和标准差[SD]，计算为20至39岁年龄范围内的平均骨密度），PA脊柱、股骨颈、转子和全股骨分别为1.116±0.12、0.927±0.12、0.756±0.11和0.963±0.13 g/cm²。85岁女性的骨密度显示，脊柱骨密度损失32%，股骨测量部位骨密度损失30%-35%。在本研究中，骨质疏松症的定义为骨密度低于或等于根据YA值确定的-2.5个标准差，50岁及以上女性受试者中，脊柱骨质疏松症患病率为28%，任何一个股骨部位为15%，任何一个脊柱或股骨部位为31%。本研究为制定中国女性骨质疏松症的预防和治疗策略提供了重要信息，并建立了一个可靠的BMD参考数据库，用于全国范围内中国女性骨质疏松症的诊断。
