磺基转移酶1A1（SULT1A1）多态性与原发性脑肿瘤易感性
Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors.
作者信息
Bardakci F, Arslan S, Bardakci S, Binatli A O, Budak M
机构信息
Department of Biology, Faculty of Science and Literature, Adnan Menderes University, 09100 Aydin, Turkey.
出版信息
J Cancer Res Clin Oncol. 2008 Jan;134(1):109-14. doi: 10.1007/s00432-007-0256-3. Epub 2007 Jun 29.
PURPOSE
Sulfotransferase 1A1 is a member of sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. The present study has investigated the association between SULT1A1 polymorphism and primary brain tumor incidence.
METHODS
SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder.
RESULTS
There was a significant difference in genotypes distribution (GG vs. GA + AA) between brain tumor patients (GG genotype frequency = 48.3%) and control population (GG genotype frequency = 65.4%; OR = 2.019, 95% CI = 1.103-3.695; P = 0.022). In order to determine the association between SULT1A1 polymorphism and specific types of brain tumors, the patients were classified according to the type of brain tumors they suffer from: glial and non-glial. Results of the statistical analyses of each group of patients in comparison with the control individuals showed a significant difference only between SULT1A1 polymorphism and non-glial brain tumors (OR = 2.615; 95% CI = 1.192-5.739; P = 0.014) but glial tumors (OR = 1.535; 95% CI = 0.688-3.425; P = 0.293). When non-glial tumors were classified as meningiomal and others (pituitary adenoma, craniopharyngioma, acoustic neuroma and hemangioblastoma), statistical analysis showed that this significance is only due to the meningiomal tumors (OR = 3.238; CI = 1.205-8.704; P = 0.015). We also estimated a reduced risk of brain tumor in non-smokers (OR = 1.700; CI = 0.800-3.615) in comparison to smokers (OR = 2.773; CI = 0.993-7.749), but this was not statistically significant.
CONCLUSION
Our findings have suggested that there was a significant association between brain tumor and SULT1A1*2 allele (A allele that is also known as His allele) and this allele is an important risk factor in the development of meningiomal brain tumors.
目的
磺基转移酶1A1是磺基转移酶家族的成员，通过硫酸化作用在多种致癌和致突变化合物的生物转化中发挥重要作用。本研究调查了SULT1A1基因多态性与原发性脑肿瘤发病率之间的关联。
方法
采用PCR-RFLP分析法成功检测了60例原发性脑肿瘤患者和156例无癌症或癌前疾病史的医院健康对照个体的SULT1A1基因型。
结果
脑肿瘤患者（GG基因型频率=48.3%）与对照人群（GG基因型频率=65.4%；OR=2.019，95%CI=1.103-3.695；P=0.022）的基因型分布（GG与GA+AA）存在显著差异。为了确定SULT1A1基因多态性与特定类型脑肿瘤之间的关联，根据患者所患脑肿瘤的类型将患者分为：神经胶质细胞瘤和非神经胶质细胞瘤。每组患者与对照个体的统计分析结果显示，仅SULT1A1基因多态性与非神经胶质细胞瘤之间存在显著差异（OR=2.615；95%CI=1.192-5.739；P=0.014），而与神经胶质细胞瘤无显著差异（OR=1.535；95%CI=0.688-3.425；P=0.293）。当将非神经胶质细胞瘤分为脑膜瘤和其他类型（垂体腺瘤、颅咽管瘤、听神经瘤和成血管细胞瘤）时，统计分析表明这种显著性仅归因于脑膜瘤（OR=3.238；CI=1.205-8.704；P=0.015）。与吸烟者（OR=2.773；CI=0.993-7.749）相比，我们还估计非吸烟者患脑肿瘤的风险降低（OR=1.700；CI=0.800-3.615），但这在统计学上并不显著。
结论
我们的研究结果表明，脑肿瘤与SULT1A1*2等位基因（也称为His等位基因的A等位基因）之间存在显著关联，该等位基因是脑膜瘤发生发展的重要危险因素。
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