Argüello Villares J L
Laboratorios Ovejero S.A., Leon, Spain.
Rev Sci Tech. 1991 Jun;10(2):459-80.
Results are presented for the large-scale use of a tissue vaccine, inactivated with beta-propiolactone and containing aluminium hydroxide adjuvant, against viral haemorrhagic disease of rabbits. The kinetics of haemagglutination-inhibiting antibodies over eighteen months, the response of vaccinated animals to challenge infection with field virus between six and fifteen months after vaccination, the serological response to revaccination, and the immunological mechanisms involved in primary vaccination and revaccination were investigated.
本文展示了使用一种用β-丙内酯灭活并含有氢氧化铝佐剂的组织疫苗大规模防治兔病毒性出血病的结果。研究了18个月内血凝抑制抗体的动力学、接种疫苗动物在接种后6至15个月对野外病毒攻击感染的反应、再次接种后的血清学反应以及初次接种和再次接种所涉及的免疫机制。
