Heller Cherrie D, O'Shea Michael, Yao Qing, Langer John, Ehrenkranz Richard A, Phelps Dale L, Poole W Kenneth, Stoll Barbara, Duara Shahnaz, Oh William, Lemons James, Poindexter Brenda
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
Our goal was to analyze the association between human milk intake and severe retinopathy of prematurity in extremely low birth weight infants.
This study is a secondary analysis of data collected for a trial of glutamine supplementation in extremely low birth weight infants (birth weight <1000 g). Among the 1433 participants in that trial, data are available regarding human milk intake and the occurrence of severe retinopathy of prematurity (defined in this study as retinopathy of prematurity treated surgically) for 1057 infants. The volume of human milk intake was expressed as the mean volume (milliliters per kilogram per day) and the mean proportional volume (proportion of total nutritional intake) from birth to discharge or transfer. Using logistic regression, we estimated odds ratios and 95% confidence intervals for any human milk intake and, among infants who received human milk, for each 10 mL/kg per day and each 10% increase in volume.
Of the 1057 infants included in this cohort, 788 infants (75%) received at least some human milk. Among these milk-fed infants, the median volume of human milk intake was 30 mL/kg per day (interquartile range: 6-83 mL/kg per day), and the median proportional volume of human milk intake was 0.18 (interquartile range: 0.03-0.66). One hundred sixty-three infants (15%) developed severe retinopathy of prematurity.
In extremely low birth weight infants, human milk intake was not associated with a decreased risk of severe retinopathy of prematurity.
我们的目标是分析极低出生体重儿的母乳摄入量与严重早产儿视网膜病变之间的关联。
本研究是对极低出生体重儿（出生体重<1000 g）谷氨酰胺补充试验所收集数据的二次分析。在该试验的1433名参与者中，有1057名婴儿的母乳摄入量和严重早产儿视网膜病变（本研究定义为接受手术治疗的早产儿视网膜病变）发生情况的数据可用。母乳摄入量以出生至出院或转院期间的平均摄入量（每天每千克毫升数）和平均比例摄入量（总营养摄入量的比例）表示。使用逻辑回归，我们估计了任何母乳摄入量以及在接受母乳的婴儿中，每天每10 mL/kg以及摄入量每增加10%时的比值比和95%置信区间。
在该队列纳入的1057名婴儿中，788名婴儿（75%）至少摄入了一些母乳。在这些母乳喂养的婴儿中，母乳摄入量的中位数为每天30 mL/kg（四分位间距：6 - 83 mL/kg/天），母乳摄入的比例中位数为0.18（四分位间距：0.03 - 0.66）。163名婴儿（15%）发生了严重早产儿视网膜病变。
在极低出生体重儿中，母乳摄入量与严重早产儿视网膜病变风险降低无关。
