Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Acta Paediatr. 2011 Mar;100(3):347-51. doi: 10.1111/j.1651-2227.2010.02069.x. Epub 2010 Nov 5.
To explore the association of serum bilirubin level and breast milk feeding with retinopathy of prematurity (ROP) in preterm infants.
We conducted a case-control study to examine the independent and combined effects of serum bilirubin and breast milk feeding on ROP risk in infants <32 weeks gestation or with birth weight <1500 g. Cases (66 infants with ROP) were matched with controls (66 infants without ROP) based on factors known to affect ROP risk.
When analysed using the paired t-test, the peak bilirubin levels were lower in ROP cases than in controls (mean 7.2 vs. 7.9 mg/dL; p = 0.045). Using conditional logistic regression, we found a negative association between highest serum bilirubin level and risk of ROP (OR = 0.82 per 1-mg/dL change in bilirubin; p = 0.06). There was no significant association between breast milk feeding and risk of ROP.
Bilirubin may help to protect preterm infants against ROP.
探讨血清胆红素水平和母乳喂养与早产儿视网膜病变（ROP）的关系。
我们进行了一项病例对照研究，以检查血清胆红素和母乳喂养对<32 周胎龄或出生体重<1500g 的早产儿 ROP 风险的独立和联合作用。根据已知影响 ROP 风险的因素，将病例（66 例 ROP 患儿）与对照组（66 例无 ROP 患儿）进行匹配。
采用配对 t 检验分析时，ROP 病例的胆红素峰值低于对照组（均值 7.2 与 7.9mg/dL；p=0.045）。采用条件 logistic 回归分析，我们发现血清胆红素最高水平与 ROP 风险呈负相关（胆红素每增加 1mg/dL，OR=0.82；p=0.06）。母乳喂养与 ROP 风险无显著相关性。
胆红素可能有助于保护早产儿免受 ROP 的侵害。
