Gesellschaft für Schwerionenforschung (GSI), Abteilung Biophysik, Planckstrasse 1, 64291 Darmstadt, Germany.
Radiat Oncol. 2007 Jul 3;2:24. doi: 10.1186/1748-717X-2-24.
At Gesellschaft für Schwerionenforschung (GSI) more than 330 patients have been treated with scanned carbon ion beams in a pilot project. To date, only stationary tumors have been treated. In the presence of motion, scanned ion beam therapy is not yet possible because of interplay effects between scanned beam and target motion which can cause severe mis-dosage. We have started a project to treat tumors that are subject to respiratory motion. A prototype beam application system for target tracking with the scanned pencil beam has been developed and commissioned. To facilitate treatment planning for tumors that are subject to organ motion, we have extended our standard treatment planning system TRiP to full 4D functionality. The 4D version of TRiP allows to calculate dose distributions in the presence of motion. Furthermore, for motion mitigation techniques tracking, gating, rescanning, and internal margins optimization of treatment parameters has been implemented. 4D calculations are based on 4D computed tomography data, deformable registration maps, organ motion traces, and beam scanning parameters.We describe the methods of our 4D treatment planning approach and demonstrate functionality of the system for phantom as well as patient data.
在德国重离子研究中心（GSI），已有超过 330 名患者在试点项目中接受了扫描碳离子束治疗。迄今为止，仅治疗了静止的肿瘤。由于扫描束和靶标运动之间的相互作用会导致严重的剂量误差，因此在存在运动的情况下，还无法进行扫描离子束治疗。我们已经开始了一个针对受呼吸运动影响的肿瘤的治疗项目。已经开发并调试了用于扫描铅笔束的目标跟踪的原型束应用系统。为了便于对受器官运动影响的肿瘤进行治疗计划，我们已经将我们的标准治疗计划系统 TRiP 扩展到了完整的 4D 功能。TRiP 的 4D 版本允许在存在运动的情况下计算剂量分布。此外，还针对运动缓解技术，实现了跟踪、门控、重扫和治疗参数的内部边界优化。4D 计算基于 4D 计算机断层扫描数据、变形配准图、器官运动轨迹和束扫描参数。我们描述了我们的 4D 治疗计划方法，并展示了该系统在体模和患者数据上的功能。
