Fulciniti Franco, Ascierto Paolo Antonio, Simeone Ester, Bove Patrizia, Losito Simona, Russo Serena, Gallo Maria Stella, Greggi Stefano
Section of Cytopathology and Dept. of Pathology, National Cancer Institute, Naples, Italy.
Cytojournal. 2007 Jul 3;4:14. doi: 10.1186/1742-6413-4-14.
Primary melanoma of the vagina is an extremely rare neoplasm with approximately 250 reported cases in the world literature 1234. In its amelanotic variant this lesion may raise several differential diagnostic problems in cytological specimens 5. In this setting, the usage of thin layer cytopathological techniques (Liquid Based Preparations = LBP) may enhance the diagnostic sensitivity by permitting immunocytochemical study without having to repeat the sampling procedure. The aim of this paper is to describe the cytomorphological presentation of primary vaginal melanoma on LBP since it has not previously been reported up to now, to our knowledge.
a 79-y-o female complaining of vulvar itching and yellowish vaginal discharge underwent a complete gynaecological evaluation during which a LBP cytological sample was taken from a suspicious whitish mass protruding into the vaginal lumen. A cytopathological diagnosis of amelanotic melanoma was rendered. The mass was radically excised and the patient was treated with alpha-Interferon.
amelanotic melanoma may be successfully diagnosed on LBP cytological preparations. Thin layer preparations may enhance the diagnostic cytomorphological clues to its diagnosis and may permit an adequate immunocytochemical characterization of the neoplasm.
原发性阴道黑色素瘤是一种极其罕见的肿瘤，世界文献中报道的病例约有250例[1-4]。在其无黑色素变体中，这种病变在细胞学标本中可能会引发一些鉴别诊断问题[5]。在这种情况下，使用薄层细胞病理学技术（液基制片 = LBP）可以通过允许进行免疫细胞化学研究而无需重复采样程序来提高诊断敏感性。据我们所知，本文的目的是描述原发性阴道黑色素瘤在LBP上的细胞形态学表现，因为此前尚未有相关报道。
一名79岁女性，因外阴瘙痒和阴道淡黄色分泌物就诊，接受了全面的妇科评估，期间从突出于阴道腔内的可疑白色肿块处采集了LBP细胞学样本。做出了无黑色素黑色素瘤的细胞病理学诊断。该肿块被根治性切除，患者接受了α-干扰素治疗。
无黑色素黑色素瘤可以在LBP细胞学制片上成功诊断。薄层制片可以增强其诊断的细胞形态学线索，并可以对肿瘤进行充分的免疫细胞化学特征描述。
