植物共生荧光假单胞菌Pf-5中一个隐秘的聚酮合酶-非核糖体肽合成酶（PKS-NRPS）基因座编码一种抗有丝分裂根霉素复合物的生物合成。

A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.

作者信息

Brendel Nicole, Partida-Martinez Laila P, Scherlach Kirstin, Hertweck Christian

机构信息

Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745 Jena, Germany.

出版信息

Org Biomol Chem. 2007 Jul 21;5(14):2211-3. doi: 10.1039/b707762a. Epub 2007 Jun 18.

DOI:10.1039/b707762a

PMID:17609750

Abstract

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS-NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

摘要

靶向基因失活和代谢谱分析表明，植物共生荧光假单胞菌Pf-5基因组中的隐秘聚酮合酶-非核糖体肽合成酶（PKS-NRPS）基因簇编码抗增殖和抗真菌根霉素衍生物的生物合成。

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植物共生荧光假单胞菌Pf-5中一个隐秘的聚酮合酶-非核糖体肽合成酶（PKS-NRPS）基因座编码一种抗有丝分裂根霉素复合物的生物合成。

A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.

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植物共生荧光假单胞菌Pf-5中一个隐秘的聚酮合酶-非核糖体肽合成酶（PKS-NRPS）基因座编码一种抗有丝分裂根霉素复合物的生物合成。

A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.

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出版信息

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