Biessy Adrien, Filion Martin
Agriculture and Agri-Food Canada, Saint-Jean-sur-Richelieu Research and Development Center, Saint-Jean-sur-Richelieu, QC J3B 7B5, Canada.
Metabolites. 2021 Mar 20;11(3):182. doi: 10.3390/metabo11030182.
Plant-beneficial spp. aggressively colonize the rhizosphere and produce numerous secondary metabolites, such as 2,4-diacetylphloroglucinol (DAPG). DAPG is a phloroglucinol derivative that contributes to disease suppression, thanks to its broad-spectrum antimicrobial activity. A famous example of this biocontrol activity has been previously described in the context of wheat monoculture where a decline in take-all disease (caused by the ascomycete ) has been shown to be associated with rhizosphere colonization by DAPG-producing spp. In this review, we discuss the biosynthesis and regulation of phloroglucinol derivatives in the genus , as well as investigate the role played by DAPG-producing spp. in natural soil suppressiveness. We also tackle the mode of action of phloroglucinol derivatives, which can act as antibiotics, signalling molecules and, in some cases, even as pathogenicity factors. Finally, we discuss the genetic and genomic diversity of DAPG-producing spp. as well as its importance for improving the biocontrol of plant pathogens.
对植物有益的菌株会积极定殖于根际，并产生大量次生代谢产物，如2,4-二乙酰基间苯三酚（DAPG）。DAPG是一种间苯三酚衍生物，因其具有广谱抗菌活性，有助于抑制病害。这种生物防治活性的一个著名例子此前已在小麦单作的背景下被描述，其中全蚀病（由子囊菌引起）的减少已被证明与产生DAPG的菌株在根际的定殖有关。在本综述中，我们讨论了该属中间苯三酚衍生物的生物合成和调控，以及研究产生DAPG的菌株在天然土壤抑制中的作用。我们还探讨了间苯三酚衍生物的作用模式，其可作为抗生素、信号分子，在某些情况下甚至作为致病因子。最后，我们讨论了产生DAPG的菌株的遗传和基因组多样性及其对改善植物病原体生物防治的重要性。
