Ikeda Masato, Minari Jusaku, Shimada Naohiko, Numata Munenori, Sakurai Kazuo, Shinkai Seiji
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Fukuoka 819-0395, Japan.
Org Biomol Chem. 2007 Jul 21;5(14):2219-24. doi: 10.1039/b705997c. Epub 2007 Jun 7.
A cationic polysaccharide bearing a beta-1,3-glucan main-chain structure (CUR-N(+)) forms a complex with a hetero-sequence oligonucleotide, that is, a CpG ODN, and facilitates the transportation of the resultant complex into a murine macrophage-like cell J774.A1, which induces an efficient secretion of a cytokine (IL-12) as compared with that induced by conventional carriers such as poly(ethyleneimine) (PEI) and poly(L-lysine) (PLL).
一种具有β-1,3-葡聚糖主链结构的阳离子多糖（CUR-N(+)）与异序寡核苷酸即CpG ODN形成复合物，并促进所得复合物转运至小鼠巨噬细胞样细胞J774.A1中，与诸如聚乙烯亚胺（PEI）和聚L-赖氨酸（PLL）等传统载体诱导的情况相比相比相比，该细胞能高效分泌细胞因子（IL-12）。
