阳离子β-1,3-葡聚糖与杂序列寡脱氧核苷酸之间的复合物形成及其向巨噬细胞样细胞的递送以诱导细胞因子分泌。
Complex formation between cationic beta-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion.
作者信息
Ikeda Masato, Minari Jusaku, Shimada Naohiko, Numata Munenori, Sakurai Kazuo, Shinkai Seiji
机构信息
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Fukuoka 819-0395, Japan.
出版信息
Org Biomol Chem. 2007 Jul 21;5(14):2219-24. doi: 10.1039/b705997c. Epub 2007 Jun 7.
A cationic polysaccharide bearing a beta-1,3-glucan main-chain structure (CUR-N(+)) forms a complex with a hetero-sequence oligonucleotide, that is, a CpG ODN, and facilitates the transportation of the resultant complex into a murine macrophage-like cell J774.A1, which induces an efficient secretion of a cytokine (IL-12) as compared with that induced by conventional carriers such as poly(ethyleneimine) (PEI) and poly(L-lysine) (PLL).
一种具有β-1,3-葡聚糖主链结构的阳离子多糖（CUR-N(+)）与异序寡核苷酸即CpG ODN形成复合物，并促进所得复合物转运至小鼠巨噬细胞样细胞J774.A1中，与诸如聚乙烯亚胺（PEI）和聚L-赖氨酸（PLL）等传统载体诱导的情况相比相比相比，该细胞能高效分泌细胞因子（IL-12）。
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