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在一名患有视网膜中央静脉阻塞和新生血管性青光眼的患者中,单次玻璃体内注射贝伐单抗后视网膜和虹膜新生血管迅速改善。

Rapid improvement of retinal and iris neovascularization after a single intravitreal bevacizumab injection in a patient with central retinal vein occlusion and neovascular glaucoma.

作者信息

Batioğlu Figen, Astam Neslihan, Ozmert Emin

机构信息

Department of Ophthalmology, Ankara University School of Medicine, Mamak yolu, Dikimevi, 06100, Ankara, Turkey.

出版信息

Int Ophthalmol. 2008 Feb;28(1):59-61. doi: 10.1007/s10792-007-9105-2. Epub 2007 Jul 4.

Abstract

BACKGROUND

Intravitreal injections of bevacizumab have been reported to have anatomical and functional success in treating choroidal neovascularization, macular edema and neovascular glaucoma. We report a case with neovascular glaucoma due to central retinal vein occlusion who demonstrates rapid resolution of anterior and posterior segment neovascularization after a single intravitreal bevacizumab injection.

CASE

A 46-year old man with a 6-month history of central retinal vein occlusion presented with neovascular glaucoma. Fluorescein angiography revealed marked leakage from new vessels on the iris, disc and retina. Bevacizumab was used after incomplete panretinal photocoagulation because of inadequate fundus visualization. About a week after intravitreal bevacizumab injection, new vessels were no longer visible. IOP improved and additional laser photocoagulation was performed.

CONCLUSION

Intravitreal bevacizumab injection may be a useful alternative or adjuvant treatment for patients with neovascular glaucoma in whom inadequate visualization precludes adequate panretinal photocoagulation.

摘要

背景

据报道,玻璃体内注射贝伐单抗在治疗脉络膜新生血管、黄斑水肿和新生血管性青光眼方面取得了解剖学和功能上的成功。我们报告了一例因视网膜中央静脉阻塞导致新生血管性青光眼的病例,该患者在单次玻璃体内注射贝伐单抗后,前后节新生血管迅速消退。

病例

一名有6个月视网膜中央静脉阻塞病史的46岁男性出现新生血管性青光眼。荧光素血管造影显示虹膜、视盘和视网膜上的新血管有明显渗漏。由于眼底观察不充分,在不完全视网膜光凝术后使用了贝伐单抗。玻璃体内注射贝伐单抗约一周后,新血管不再可见。眼压改善,并进行了额外的激光光凝。

结论

对于因观察不充分而无法进行充分视网膜光凝的新生血管性青光眼患者,玻璃体内注射贝伐单抗可能是一种有用的替代或辅助治疗方法。

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