Haddad Maha, Lau Keith, Butani Lavjay
Department of Pediatrics, Section of Nephrology, University of California Davis Medical Center, 2516 Stockton Boulevard, Sacramento, CA 95817, USA.
Pediatr Nephrol. 2007 Oct;22(10):1787-91. doi: 10.1007/s00467-007-0523-1. Epub 2007 Jul 3.
Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic-nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.
膜增生性肾小球肾炎虽不常见，但在儿童中与相当高的发病率和死亡率相关。皮质类固醇是重症疾病治疗的主要手段，尽管支持其使用的数据有限。我们报告了治疗两名患有特发性膜增生性肾小球肾炎所致肾病-肾炎综合征儿童的经验。两名儿童对长期使用类固醇的反应均不理想，遂开始使用他克莫司作为类固醇节约剂。在开始使用他克莫司后，两名儿童均迅速且完全缓解。我们报告的目的是提高医护人员对该药物在诱导重症膜增生性肾小球肾炎儿童缓解方面潜在益处的认识。
