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本文引用的文献

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Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background.非志贺毒素相关性溶血尿毒综合征患者肾移植的结局：遗传背景的预后意义
Clin J Am Soc Nephrol. 2006 Jan;1(1):88-99. doi: 10.2215/CJN.00050505. Epub 2005 Nov 2.
2
New approaches to the treatment of dense deposit disease.治疗致密物沉积病的新方法。
J Am Soc Nephrol. 2007 Sep;18(9):2447-56. doi: 10.1681/ASN.2007030356. Epub 2007 Aug 5.
3
A descriptive study of individuals with membranoproliferative glomerulonephritis.一项关于膜增生性肾小球肾炎患者的描述性研究。
Nephrol Nurs J. 2007 May-Jun;34(3):295-302; quiz 303.
4
Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus.使用他克莫司使Ⅰ型膜增生性肾小球肾炎缓解。
Pediatr Nephrol. 2007 Oct;22(10):1787-91. doi: 10.1007/s00467-007-0523-1. Epub 2007 Jul 3.
5
Mycophenolate mofetil treatment for therapy-resistant glomerulopathies.霉酚酸酯治疗难治性肾小球病
Nephrology (Carlton). 2007 Jun;12(3):285-8. doi: 10.1111/j.1440-1797.2006.00763.x.
6
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.抗因子H自身抗体在溶血尿毒综合征中阻断因子H的C端识别功能。
Blood. 2007 Sep 1;110(5):1516-8. doi: 10.1182/blood-2007-02-071472. Epub 2007 May 10.
7
Dense deposit disease: new insights.致密沉积物病：新见解
Curr Opin Nephrol Hypertens. 2007 May;16(3):204-12. doi: 10.1097/MNH.0b013e3280bdc0f4.
8
Complete factor H deficiency-associated atypical hemolytic uremic syndrome in a neonate.新生儿完全性补体因子H缺乏相关的非典型溶血尿毒综合征
Pediatr Nephrol. 2007 Jun;22(6):874-80. doi: 10.1007/s00467-007-0438-x. Epub 2007 Feb 13.
9
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.补体因子B的功能获得性突变与非典型溶血性尿毒症综合征相关。
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):240-5. doi: 10.1073/pnas.0603420103. Epub 2006 Dec 20.
10
A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome.补体I因子（IF）的错义突变易导致非典型溶血尿毒综合征。
Pediatr Nephrol. 2007 Mar;22(3):371-5. doi: 10.1007/s00467-006-0320-2. Epub 2006 Nov 15.

补体因子H的转化性小型综述系列：与补体因子H异常相关的肾脏疾病的治疗：非典型溶血尿毒综合征和膜增生性肾小球肾炎

Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.

作者信息

Noris M, Remuzzi G

机构信息

Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Villa Camozzi - Ranica (BG), Italy.

出版信息

Clin Exp Immunol. 2008 Feb;151(2):199-209. doi: 10.1111/j.1365-2249.2007.03558.x. Epub 2007 Dec 7.

DOI:10.1111/j.1365-2249.2007.03558.x
PMID:18070148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2276938/
Abstract

Genetic and acquired abnormalities in complement factor H (CFH) have been associated with two different human renal diseases: haemolytic uraemic syndrome and membrano proliferative glomerulonephritis. The new genetic and pathogenetic findings in these diseases and their clinical implications for the management and cure of patients are reviewed in this paper.

摘要

补体因子H（CFH）的遗传和后天异常与两种不同的人类肾脏疾病相关：溶血性尿毒症综合征和膜增生性肾小球肾炎。本文综述了这些疾病的新遗传和发病机制研究结果及其对患者管理和治疗的临床意义。