Eddy Kamryn T, Dorer David J, Franko Debra L, Tahilani Kavita, Thompson-Brenner Heather, Herzog David B
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Int J Eat Disord. 2007 Nov;40 Suppl:S67-71. doi: 10.1002/eat.20422.
To determine whether a past diagnosis of anorexia nervosa (AN) predicts longitudinal course and outcome among women with bulimia nervosa (BN).
A subset (n = 176) of participants in the Longitudinal Study of Anorexia and Bulimia Nervosa who met DSM-IV criteria for BN either at study intake (n = 144) or during follow-up (n = 32; 4 had restricting AN at intake, 28 had binge/purge AN at intake) were included in this report. Over a median of 9 years, weekly eating disorder symptom data were collected from participants using the Longitudinal Interview Follow-up Examination, Eating Disorders Version.
While there were no between-group differences in likelihood of partial recovery, women with BN who had a history of AN were more likely to have a protracted illness, relapsing into AN during follow-up, compared to those with no AN history who were more likely to move from partial to full recovery.
Lifetime AN is an important prognostic indicator among women with BN and these longitudinal data would support the subtyping of BN on the basis of AN history.
确定过去神经性厌食症（AN）的诊断是否能预测神经性贪食症（BN）女性的病程及结局。
本报告纳入了神经性厌食症和神经性贪食症纵向研究中的一个子集（n = 176），这些参与者在研究入组时（n = 144）或随访期间（n = 32；4人在入组时为限制型AN，28人在入组时为暴食/清除型AN）符合DSM-IV标准的BN。在中位时间9年里，使用纵向访谈随访检查（饮食失调版）从参与者处收集每周的饮食失调症状数据。
虽然部分康复的可能性在组间没有差异，但有AN病史的BN女性比没有AN病史的女性更易患迁延性疾病，在随访期间复发为AN，而无AN病史者更可能从部分康复转变为完全康复。
终生AN是BN女性的一个重要预后指标，这些纵向数据支持根据AN病史对BN进行亚型分类。
