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Etomidate, sepsis, and adrenal function: not as bad as we thought?
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Controversies surrounding the use of etomidate for rapid sequence intubation in patients with suspected sepsis.
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Etomidate for critically ill patients. Pro: yes we can use it.
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Etomidate as an Induction Agent in Sepsis.
Crit Care Nurs Clin North Am. 2018 Sep;30(3):e1-e9. doi: 10.1016/j.cnc.2018.05.004. Epub 2018 Jul 13.
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Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Lancet. 2009 Jul 25;374(9686):293-300. doi: 10.1016/S0140-6736(09)60949-1. Epub 2009 Jul 1.
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Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients?
Am J Emerg Med. 2008 Feb;26(2):229-32. doi: 10.1016/j.ajem.2007.03.032.
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Etomidate versus ketamine for sedation in acutely ill patients.
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1
The preclinical pharmacological study of a novel intravenous anesthetic, ET-26 hydrochloride, in aged rats.
PeerJ. 2022 Sep 29;10:e13995. doi: 10.7717/peerj.13995. eCollection 2022.
2
Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs.
Front Pharmacol. 2021 May 31;12:679381. doi: 10.3389/fphar.2021.679381. eCollection 2021.
3
Effects of continuous infusion of etomidate at various dose rates on adrenal function in dogs.
BMC Anesthesiol. 2016 Jan 8;16:2. doi: 10.1186/s12871-015-0171-0.
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Does etomidate increase vasopressor requirements in patients needing mechanical ventilation?
Can J Hosp Pharm. 2012 Jul;65(4):272-6. doi: 10.4212/cjhp.v65i4.1157.
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Etomidate and mortality in cirrhotic patients with septic shock.
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The effect of etomidate on adrenal function in critical illness: a systematic review.
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The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock.
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Duration of adrenal inhibition following a single dose of etomidate in critically ill patients.
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Adrenal function in sepsis: the retrospective Corticus cohort study.
Crit Care Med. 2007 Apr;35(4):1012-8. doi: 10.1097/01.CCM.0000259465.92018.6E.
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Predictors of hypotension after induction of general anesthesia.
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Etomidate and intensive care physicians.
Intensive Care Med. 2005 Oct;31(10):1453; author reply 1454. doi: 10.1007/s00134-005-2754-6. Epub 2005 Aug 11.
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Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis.
BMJ. 2004 Aug 28;329(7464):480. doi: 10.1136/bmj.38181.482222.55. Epub 2004 Aug 2.
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Measurements of serum free cortisol in critically ill patients.
N Engl J Med. 2004 Apr 15;350(16):1629-38. doi: 10.1056/NEJMoa020266.
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A review of etomidate for rapid sequence intubation in the emergency department.
J Emerg Med. 1997 Mar-Apr;15(2):221-30. doi: 10.1016/s0736-4679(96)00350-2.
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Inhibition of adrenal steroidogenesis by the anesthetic etomidate.
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