帕金森病患者单次舌下含服阿扑吗啡后血浆浓度与临床疗效的关系。
Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.
作者信息
Durif F, Jeanneau E, Serre-Debeauvais F, Deffond D, Eschalier A, Tournilhac M
机构信息
Clinique Neurologique, CHU Clermont Ferrand, France.
出版信息
Eur J Clin Pharmacol. 1991;41(5):493-4. doi: 10.1007/BF00626377.
PMID:1761081
Abstract
Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.
摘要
五名帕金森病患者舌下含服了单剂量的3毫克片剂阿扑吗啡（2名患者服用18毫克，3名患者服用39毫克）。治疗效果在33.0分钟内出现，持续137分钟。峰值浓度、曲线下面积、剂量（毫克/千克）与治疗效果持续时间之间存在显著相关性。
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