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帕金森病患者单次舌下含服阿扑吗啡后血浆浓度与临床疗效的关系。

Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.

作者信息

Durif F, Jeanneau E, Serre-Debeauvais F, Deffond D, Eschalier A, Tournilhac M

机构信息

Clinique Neurologique, CHU Clermont Ferrand, France.

出版信息

Eur J Clin Pharmacol. 1991;41(5):493-4. doi: 10.1007/BF00626377.

DOI:10.1007/BF00626377
PMID:1761081
Abstract

Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.

摘要

五名帕金森病患者舌下含服了单剂量的3毫克片剂阿扑吗啡（2名患者服用18毫克，3名患者服用39毫克）。治疗效果在33.0分钟内出现，持续137分钟。峰值浓度、曲线下面积、剂量（毫克/千克）与治疗效果持续时间之间存在显著相关性。

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Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.帕金森病患者单次舌下含服阿扑吗啡后血浆浓度与临床疗效的关系。
Eur J Clin Pharmacol. 1991;41(5):493-4. doi: 10.1007/BF00626377.
2
Relation between clinical efficacy and pharmacokinetic parameters after sublingual apomorphine in Parkinson's disease.帕金森病患者舌下含服阿扑吗啡后的临床疗效与药代动力学参数之间的关系
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Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease.帕金森病患者中阿扑吗啡的药代动力学-药效学关系。
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本文引用的文献

1
Determination of apomorphine in rat plasma and brain by high-performance liquid chromatography with electrochemical detection.采用高效液相色谱-电化学检测法测定大鼠血浆和脑中的阿扑吗啡。
J Chromatogr. 1985 Feb 27;338(1):230-5. doi: 10.1016/0378-4347(85)80091-8.
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Subcutaneous apomorphine in Parkinson's disease.帕金森病中的皮下注射阿扑吗啡
Lancet. 1988 Apr 23;1(8591):943. doi: 10.1016/s0140-6736(88)91755-2.
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Subcutaneous apomorphine in parkinsonian on-off oscillations.皮下注射阿扑吗啡治疗帕金森病的开关现象
帕金森病治疗中的药代动力学优化
Clin Pharmacokinet. 1996 Jun;30(6):463-81. doi: 10.2165/00003088-199630060-00004.
Lancet. 1988 Feb 20;1(8582):403-6. doi: 10.1016/s0140-6736(88)91193-2.
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Sublingual apomorphine and Parkinson's disease.舌下含服阿扑吗啡与帕金森病
J Neurol Neurosurg Psychiatry. 1989 Dec;52(12):1440. doi: 10.1136/jnnp.52.12.1440.
5
[Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease].[皮下注射阿扑吗啡治疗帕金森病运动波动]
Rev Neurol (Paris). 1990;146(2):116-22.
6
Efficacy of sublingual apomorphine in Parkinson's disease.舌下含服阿扑吗啡治疗帕金森病的疗效
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1105. doi: 10.1136/jnnp.53.12.1105.
7
Treatment of Parkinson's disease with aporphines. Possible role of growth hormone.阿朴啡类药物治疗帕金森病。生长激素的可能作用。
N Engl J Med. 1976 Mar 11;294(11):567-72. doi: 10.1056/NEJM197603112941101.
8
Onset and end-of-dose levodopa-induced dyskinesias. Possible treatment by increasing the daily doses of levodopa.左旋多巴诱发异动症的起始与剂末现象。增加左旋多巴每日剂量的可能治疗方法。
Arch Neurol. 1978 May;35(5):261-3. doi: 10.1001/archneur.1978.00500290007002.