关于雷斯顿埃博拉病毒低毒力的现有知识（法语：Connaissances actuelles sur la moindre virulence du virus Ebola Reston）
Current knowledge on lower virulence of Reston Ebola virus (in French: Connaissances actuelles sur la moindre virulence du virus Ebola Reston).
作者信息
Morikawa Shigeru, Saijo Masayuki, Kurane Ichiro
机构信息
Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.
出版信息
Comp Immunol Microbiol Infect Dis. 2007 Sep;30(5-6):391-8. doi: 10.1016/j.cimid.2007.05.005. Epub 2007 Jul 3.
Ebola viruses (EBOV) and Marburg virus belong to the family Filoviridae, order Mononegavirales. The genus Ebolavirus consists of four species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Ivory Coast ebolavirus (ICEBOV) and Reston ebolavirus (REBOV). Three species of ebolaviruses, ZEBOV, SEBOV, ICEBOV, and Marburg virus are known to be extremely pathogenic in primates and humans and cause severe hemorrhagic fever leading up to case fatality rate of some 90%, while REBOV is thought to be pathogenic in Asian monkeys but not in African monkeys and humans. Recent studies indicated several factors involved in different virulence between African EBOV and REBOV. This article reviews the history, epidemiology, and virulence of REBOV.
埃博拉病毒（EBOV）和马尔堡病毒属于单股负链RNA病毒目丝状病毒科。埃博拉病毒属包含四个种：扎伊尔埃博拉病毒（ZEBOV）、苏丹埃博拉病毒（SEBOV）、科特迪瓦埃博拉病毒（ICEBOV）和莱斯顿埃博拉病毒（REBOV）。已知三种埃博拉病毒，即ZEBOV、SEBOV、ICEBOV以及马尔堡病毒对灵长类动物和人类具有极高的致病性，可引发严重出血热，致死率约为90%，而REBOV被认为对亚洲猴具有致病性，但对非洲猴和人类无致病性。近期研究表明，非洲EBOV和REBOV之间存在不同毒力的若干影响因素。本文综述了REBOV的历史、流行病学及毒力。
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