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引用本文的文献

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本文引用的文献

1
Secondary prevention with folic acid: results of the Goes extension study.叶酸二级预防：Goes扩展研究结果
Heart. 2005 Sep;91(9):1213-4. doi: 10.1136/hrt.2004.035030.
2
Folate therapy and in-stent restenosis after coronary stenting.叶酸治疗与冠状动脉支架置入术后支架内再狭窄
N Engl J Med. 2004 Jun 24;350(26):2673-81. doi: 10.1056/NEJMoa032845.
3
Effect of folic acid fortification of food on homocysteine-related mortality.食物叶酸强化对同型半胱氨酸相关死亡率的影响。
Am J Med. 2004 Feb 1;116(3):158-64. doi: 10.1016/j.amjmed.2003.10.024.
4
Decreased rate of coronary restenosis after lowering of plasma homocysteine levels.血浆同型半胱氨酸水平降低后冠状动脉再狭窄率降低。
N Engl J Med. 2001 Nov 29;345(22):1593-600. doi: 10.1056/NEJMoa011364.
5
Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration.使用含叶酸补充剂降低血液同型半胱氨酸水平：随机试验的荟萃分析。同型半胱氨酸降低试验协作组
BMJ. 1998 Mar 21;316(7135):894-8.
6
Homocysteine and atherothrombosis.同型半胱氨酸与动脉粥样硬化血栓形成
N Engl J Med. 1998 Apr 9;338(15):1042-50. doi: 10.1056/NEJM199804093381507.
7
Heart attacks and homocysteine.心脏病发作与同型半胱氨酸
BMJ. 1996 Dec 7;313(7070):1419-20. doi: 10.1136/bmj.313.7070.1419.
8
Risk factors of coronary heart disease and total mortality among elderly men with and without preexisting coronary heart disease. Finnish cohorts of the Seven Countries Study.患有和未患有冠心病的老年男性中冠心病和总死亡率的危险因素。七国研究的芬兰队列。
J Am Coll Cardiol. 1995 Dec;26(7):1623-9. doi: 10.1016/0735-1097(95)00395-9.
9
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.血浆同型半胱氨酸作为血管疾病危险因素的定量评估。增加叶酸摄入量的潜在益处。
JAMA. 1995 Oct 4;274(13):1049-57. doi: 10.1001/jama.1995.03530130055028.

叶酸治疗是否能降低冠状动脉再狭窄的风险？

Does folate therapy reduce the risk of coronary restenosis?

机构信息

Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.

出版信息

Neth Heart J. 2007 Jan;15(1):12-5. doi: 10.1007/BF03086052.

DOI:10.1007/BF03086052
PMID:17612702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1847724/
Abstract

BACKGROUND.: A high homocysteine level is associated with an increased risk of ischaemic heart disease. Folate therapy has shown to reduce the homocysteine blood level, but does it decrease the risk of coronary restenosis in patients with coronary arterial disease? METHODS.: A systematic online literature search followed by a critical appraisal resulted in three suitable articles to provide an evidence-based evaluation of this clinical query. RESULTS.: The rate of coronary restenosis was reduced after folate therapy, except in patients who have had coronary stenting. An adverse effect of folate therapy on in-stent coronary restenosis was observed. CONCLUSION.: The effects of folate therapy on the rate of coronary restenosis after balloon angioplasty are contradicting. Until more clinical research has been preformed we recommend a conservative attitude towards folate therapy. (Neth Heart J 2007;15:12-5.).

摘要

背景

高同型半胱氨酸水平与缺血性心脏病的风险增加有关。叶酸治疗已被证明可降低血液同型半胱氨酸水平，但它是否会降低冠状动脉疾病患者的冠状动脉再狭窄风险？

方法

系统的在线文献检索，随后进行批判性评估，得出了三篇合适的文章，为这一临床问题提供了循证评估。

结果

除了接受冠状动脉支架植入术的患者外，叶酸治疗后冠状动脉再狭窄的发生率降低。观察到叶酸治疗对支架内冠状动脉再狭窄有不良影响。

结论

叶酸治疗对球囊血管成形术后冠状动脉再狭窄率的影响存在矛盾。在进行更多的临床研究之前，我们建议对叶酸治疗持保守态度。（荷兰心脏杂志 2007 年；15：12-5.）。