水牛GDF 8（肌肉生长抑制素）基因序列

Sequence of GDF 8 (myostatin) gene in Bubalus bubalis.

作者信息

Tantia M S, Vijh R K, Mishra B, Kumar S T Bharani

机构信息

National Bureau of Animal Genetic Resources, Karnal, Haryana, India.

出版信息

Anim Biotechnol. 2007;18(3):177-81. doi: 10.1080/10495390601115526.

DOI:10.1080/10495390601115526

PMID:17612840

Abstract

The sequence of myostatin gene (growth differentiation factor 8 [GDF 8]) in Indian riverine buffalo (Bubalus bubalis) is reported. The genomic DNA as well as mRNA were sequenced. The sequence is conserved across all the livestock species. Five nonsynonymous changes as compared to cattle were found in this study and were also confirmed by mRNA sequence. Two intronic single nucleotide polymorphisms (SNPs) were identified in buffalo.

摘要

报道了印度河流水牛（Bubalus bubalis）中肌肉生长抑制素基因（生长分化因子8 [GDF 8]）的序列。对基因组DNA以及mRNA进行了测序。该序列在所有家畜物种中都是保守的。本研究发现与牛相比有五个非同义变化，并且mRNA序列也证实了这些变化。在水牛中鉴定出两个内含子单核苷酸多态性（SNP）。