Stummer Walter
Department of Neurosurgery, Düsseldorf, Germany.
Neurosurg Focus. 2007 May 15;22(5):E8. doi: 10.3171/foc.2007.22.5.9.
Cerebral edema contributes strongly to symptoms associated with brain tumors. Although the introduction of corticosteroids has greatly simplified treatment of patients with newly diagnosed tumors, these drugs are associated with marked side effects during the long-term treatment that is often necessary in the recurrences. Therefore, a better understanding of mechanisms related to the evolution and clearance of tumor-related edema with the aid of modern imaging and molecular methodology is clearly necessary. Recently, researchers have focused on molecular mechanisms of edema development and have demonstrated alternative routes-such as the inhibition of vascular endothelial growth factor receptor inhibitors-to be explored for treating edema. In this review the author focuses on established and current concepts regarding the pathophysiology of cerebral edema and its treatment.
脑水肿在脑肿瘤相关症状中起重要作用。尽管皮质类固醇的应用极大地简化了新诊断肿瘤患者的治疗，但这些药物在复发时常常需要的长期治疗过程中会产生明显的副作用。因此，借助现代影像学和分子方法更好地了解与肿瘤相关水肿的发生发展及清除相关的机制显然是必要的。最近，研究人员聚焦于水肿形成的分子机制，并已证明可探索如抑制血管内皮生长因子受体抑制剂等替代途径来治疗水肿。在这篇综述中，作者重点介绍了关于脑水肿病理生理学及其治疗的既定概念和当前观点。
