Syed Deeba N, Afaq Farrukh, Mukhtar Hasan
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
Semin Cancer Biol. 2007 Oct;17(5):377-85. doi: 10.1016/j.semcancer.2007.05.004. Epub 2007 May 29.
Because treatment options for advanced metastasized cancers remain inadequate, developing effective approaches for the prevention of cancer has become an important goal to reduce cancer burden. One such strategy is through chemoprevention, preferably by the use of non-toxic dietary substances and botanical products. Pomegranate, used for centuries for its medicinal properties is now being recognized as a potential chemopreventive and anticancer agent. Increasing body of evidence has underscored the cancer preventive efficacy of pomegranate both in vitro and in vivo animal models. The emerging data provide new insights into the molecular framework needed to establish novel mechanism-based chemopreventive strategies for various human cancers.
由于晚期转移性癌症的治疗选择仍然不足，开发有效的癌症预防方法已成为减轻癌症负担的重要目标。一种这样的策略是通过化学预防，最好是使用无毒的饮食物质和植物产品。石榴，因其药用特性已被使用了几个世纪，现在被认为是一种潜在的化学预防和抗癌剂。越来越多的证据强调了石榴在体外和体内动物模型中的癌症预防功效。新出现的数据为建立针对各种人类癌症的基于新机制的化学预防策略所需的分子框架提供了新的见解。
