Smyth Shane, Menkes Daniel L
Department of Neurology, University of Tennessee Health Sciences Center at Memphis, 855 Monroe Avenue, Link 415, Memphis, Tennessee 38163, USA.
Muscle Nerve. 2008 Jan;37(1):130-5. doi: 10.1002/mus.20841.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and membranous glomerulonephritis (MGN) are both autoimmune disorders that are rarely observed concurrently. We describe a patient who developed MGN nearly 20 years after the onset of CIDP, resulting in a secondary progression of his neuropathy. He responded dramatically to a novel regimen of plasma exchange and methotrexate. We propose a mechanism other than autoimmunity for the coincidence of these disorders and discuss the theoretical superiority of the treatment regimen that he received.
慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）和膜性肾小球肾炎（MGN）均为自身免疫性疾病，很少同时出现。我们描述了一名患者，在CIDP发病近20年后发生了MGN，导致其神经病变继发进展。他对一种新的血浆置换和甲氨蝶呤治疗方案反应显著。我们提出了一种不同于自身免疫的机制来解释这些疾病的巧合，并讨论了他所接受治疗方案的理论优势。
