Pool John E, Aquadro Charles F
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Mol Ecol. 2007 Jul;16(14):2844-51. doi: 10.1111/j.1365-294X.2007.03324.x.
In a broad survey of Drosophila melanogaster population samples, levels of abdominal pigmentation were found to be highly variable and geographically differentiated. A strong positive correlation was found between dark pigmentation and high altitude, suggesting adaptation to specific environments. DNA sequence polymorphism at the candidate gene ebony revealed a clear association with the pigmentation of homozygous third chromosome lines. The darkest lines sequenced had nearly identical haplotypes spanning 14.5 kb upstream of the protein-coding exons of ebony. Thus, natural selection may have elevated the frequency of an allele that confers dark abdominal pigmentation by influencing the regulation of ebony.
在对黑腹果蝇种群样本的广泛调查中,发现腹部色素沉着水平高度可变且存在地理差异。深色色素沉着与高海拔之间存在强烈的正相关,表明对特定环境的适应。候选基因乌木的DNA序列多态性揭示了与纯合第三染色体品系色素沉着的明显关联。测序的最深色品系在乌木蛋白编码外显子上游14.5 kb范围内具有几乎相同的单倍型。因此,自然选择可能通过影响乌木的调控提高了赋予深色腹部色素沉着的等位基因的频率。