从朝鲜粗榧叶中分离得到的一种新黄酮苷。

A new flavonoid glycoside from the leaf of Cephalotaxus koreana.

作者信息

Bae Kihwan, Jin Wenyi, Thuong Phuong Thien, Min Byung Sun, Na Minkyun, Lee Young Mi, Kang Sam Sik

机构信息

College of Pharmacy, Chungnam National University, Daejeon, South Korea.

出版信息

Fitoterapia. 2007 Sep;78(6):409-13. doi: 10.1016/j.fitote.2007.02.008. Epub 2007 Apr 11.

DOI:10.1016/j.fitote.2007.02.008

PMID:17616262

Abstract

A new flavone glycoside, apigenin 5-O-alpha-L-rhamnopyranosyl-(1-->3)-beta-D-glucopyranoside (1), along with four known flavonol glycosides (2-5), were isolated from the leaf of Cephalotaxus koreana. The new glycoside 1 showed inhibitory activity in superoxide radical scavenging assay with IC(50) value of 13.0 microM, while it showed weak activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Compounds 2-5 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC(50) values ranging from 5.7 to 22.3 microM.

摘要

从朝鲜红豆杉叶中分离得到一种新的黄酮糖苷，芹菜素5 - O-α-L-鼠李糖基-(1→3)-β-D-葡萄糖苷（1），以及四种已知的黄酮醇糖苷（2 - 5）。新糖苷1在超氧阴离子自由基清除试验中表现出抑制活性，IC(50)值为13.0 μM，而在1,1-二苯基-2-苦基肼（DPPH）自由基清除试验中表现出较弱的活性。化合物2 - 5在清除DPPH和超氧阴离子自由基方面表现出抗氧化活性，IC(50)值在5.7至22.3 μM之间。