Ribu Lis, Hanestad Berit Rokne, Moum Torbjorn, Birkeland Kåre, Rustoen Tone
Oslo University College, Faculty of Nursing, 0130 Oslo, Norway.
J Diabetes Complications. 2007 Jul-Aug;21(4):227-36. doi: 10.1016/j.jdiacomp.2007.02.001.
The purpose of the study was to describe the sociodemographic variables, clinical characteristics, and treatment factors in patients with diabetic foot ulcers (DFU) and to explore the associations between these factors and the patients' health-related quality of life (HRQL).
Cross-sectional data were obtained from 127 patients consecutively recruited from six hospital outpatient clinics. The patients were over 20 years of age, had current DFU, and had been diagnosed with diabetes of either Type 1 or Type 2. Data were obtained by clinical and laboratory examination and by self-completed questionnaires (SF-36). Descriptive analyses, bivariate analyses, and hierarchical regression analyses in three blocks were performed.
The patients' mean age was 60 years (S.D., 13.8 years); 72% were men, and 29% had Type 1 diabetes. The most important variables explaining the variance in HRQL were the presence of biochemical signs of inflammation as measured by the detection of C-reactive protein (CRP) >10 mg/l, an ankle-brachial index (ABI) <0.9, an ulcer size > or =5 cm(2), nephropathy, and a body mass index <25 kg/m(2). The strongest association occurred between biochemical signs of inflammation CRP >10 mg/l, ABI <0.9, ulcer size >5 cm(2), and HRQL on physical functioning (adjusted r(2)=24). A major part of the variance remained unexplained and should be investigated in future studies.
The findings may tend to identify the most vulnerable subgroups among those with DFU and may be useful in the formulation of strategies to improve function and HRQL in these patients.
本研究旨在描述糖尿病足溃疡（DFU）患者的社会人口统计学变量、临床特征和治疗因素，并探讨这些因素与患者健康相关生活质量（HRQL）之间的关联。
横断面数据来自于从六个医院门诊连续招募的127名患者。患者年龄超过20岁，患有现患DFU，且已被诊断为1型或2型糖尿病。通过临床和实验室检查以及自行填写的问卷（SF - 36）获取数据。进行了描述性分析、双变量分析以及分三个模块的分层回归分析。
患者的平均年龄为60岁（标准差为13.8岁）；72%为男性，29%患有1型糖尿病。解释HRQL方差的最重要变量是通过检测C反应蛋白（CRP）>10 mg/l测得的炎症生化指标、踝臂指数（ABI）<0.9、溃疡面积>或 =5 cm²、肾病以及体重指数<25 kg/m²。炎症生化指标CRP >10 mg/l、ABI <0.9、溃疡面积>5 cm²与身体功能方面的HRQL之间存在最强的关联（调整后的r² = 24）。大部分方差仍无法解释，应在未来研究中进行调查。
这些发现可能有助于识别DFU患者中最脆弱的亚组，并可能有助于制定改善这些患者功能和HRQL的策略。
