糖尿病高危足溃疡患者的健康相关生活质量及其相关因素。
Health-related quality of life and associated factors in people with diabetes at high risk of foot ulceration.
机构信息
La Trobe Rural Health School, La Trobe University, PO Box 199, Bendigo, Victoria, 3552, Australia.
Amsterdam UMC, location University of Amsterdam, Rehabilitation Medicine, Meibergdreef 9, Amsterdam, The Netherlands.
出版信息
J Foot Ankle Res. 2022 Nov 18;15(1):83. doi: 10.1186/s13047-022-00586-9.
BACKGROUND
The health-related quality of life (HRQoL) of people with diabetes-related foot complications has been increasingly reported, mostly from studies of people with a foot ulcer. The aim of this study was to assess HRQoL and determine factors associated with HRQoL in people with diabetes at high risk of foot ulceration.
METHODS
In all, 304 participants enrolled in the Diabetic Foot Temperature Trial (DIATEMP) were included in the cross-sectional analysis. HRQoL was measured by the RAND® 36-Item Short Form Health Survey (SF-36) at baseline. Potential factors associated with HRQoL were analysed using multiple linear regression analyses for the eight domains of the SF-36.
RESULTS
Participants were predominantly male (72%), mean age 64.6 (±10.5) years, 77% type 2 diabetes and mean duration of diabetes 20 (±14) years. Mean SF-36 domain scores for the General Health (49.2 ± 20.1), Role Physical (50.9 ± 44.7), Physical Function (58.5 ± 27.9) and Vitality domains (59.8 ± 21.6) were lower compared to the Mental Health (78.4 ± 18.0), Social Functioning (75.3 ± 24.2), Role Emotional (73.5 ± 38.9) and Bodily Pain (67.0 ± 27.0) domains. HRQoL was lower than Dutch population-based and general diabetes samples, but higher than in samples with an ulcer. Use of a walking aid was associated with lower HRQoL across all 8 SF-36 domains (β range - 0.20 to - 0.50), non-Caucasian descent was associated with lower HRQoL in 5 domains (β range - 0.13 to - 0.17). Not working, higher BMI and younger age were associated with lower HRQoL in 3 domains.
CONCLUSIONS
People at high risk of diabetes-related foot ulceration have reduced HRQoL that varies across domains, with the physical domains most affected. Assessing mobility, ethnicity, BMI and job status may be useful in daily practice to screen for people who might benefit from interventions targeting HRQoL.
TRIAL REGISTRATION
Netherlands Trial Registration: NTR5403. Registered on 8 September 2015.
背景
与糖尿病相关的足部并发症患者的健康相关生活质量（HRQoL）越来越受到关注，主要来自足部溃疡患者的研究。本研究旨在评估糖尿病高危足溃疡患者的 HRQoL，并确定与 HRQoL 相关的因素。
方法
共纳入 304 名参与糖尿病足温度试验（DIATEMP）的患者进行横断面分析。基线时使用 RAND®36 项简短健康调查（SF-36）测量 HRQoL。使用多元线性回归分析 SF-36 的 8 个领域分析与 HRQoL 相关的潜在因素。
结果
参与者主要为男性（72%），平均年龄 64.6（±10.5）岁，77%为 2 型糖尿病，糖尿病病程 20（±14）年。SF-36 各领域的平均得分如下：一般健康（49.2±20.1）、身体角色（50.9±44.7）、身体功能（58.5±27.9）和活力（59.8±21.6）领域的评分低于心理健康（78.4±18.0）、社会功能（75.3±24.2）、情绪角色（73.5±38.9）和躯体疼痛（67.0±27.0）领域。与荷兰基于人群和一般糖尿病样本相比，HRQoL 较低，但高于溃疡样本。使用助行器与所有 8 个 SF-36 领域的 HRQoL 较低有关（β范围-0.20 至-0.50），非白种人后裔与 5 个领域的 HRQoL 较低有关（β范围-0.13 至-0.17）。不工作、较高的 BMI 和较年轻的年龄与 3 个领域的 HRQoL 较低有关。
结论
糖尿病高危足溃疡患者的 HRQoL 降低，各领域的 HRQoL 存在差异，身体领域受影响最大。评估移动能力、种族、BMI 和工作状态可能有助于在日常实践中筛查可能受益于针对 HRQoL 干预的人群。
试验注册
荷兰试验注册：NTR5403。于 2015 年 9 月 8 日注册。
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